Development of new self-assembled cationic amino liposomes for efficient gene delivery

Yihang Wu, Yue Xiong, Ling Wang, Quanming Zhou, Linxian Li, Pavel A. Levkin, Gary Davidson, Liqian Gao, Wenbin Deng

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A library of 83 structurally diverse cationic amino liposomes is rationally designed and parallelly synthesized for the transfection of plasmid DNA and siRNA. Our designed self-assembled liposomes not only exhibit excellent transfection efficiency in HEK 293T cells and mouse embryonic stem cells, but also show low cytotoxicity.

Original languageEnglish (US)
Pages (from-to)3021-3025
Number of pages5
JournalBiomaterials Science
Volume8
Issue number11
DOIs
StatePublished - Jun 7 2020
Externally publishedYes

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)

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