Development of monoclonal antibody imaging of metastatic prostatic carcinoma

Frederick J Meyers, S. J. Denardo, D. Macey, Ralph W deVere White, M. Unger

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Indium-111-labeled monoclonal antibody directed against prostate-specific antigen was injected into ten patients with known prostatic carcinoma, nine with metastatic disease. The monoclonal antibody scan was compared to the standard technetium bone scan, and both were correlated to clinical status and to 2-year follow-up. The ratio of target-to-nontarget activity and pharmacokinetics of the radiolabeled antibody approach may be used for staging and may be developed as a therapeutic adjuvant.

Original languageEnglish (US)
Pages (from-to)209-220
Number of pages12
JournalProstate
Volume14
Issue number3
StatePublished - 1989

ASJC Scopus subject areas

  • Urology

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