Development of monoclonal antibody imaging of metastatic prostatic carcinoma

Frederick J Meyers; S. J. Denardo; D. Macey; Ralph W deVere White; M. Unger

Development of monoclonal antibody imaging of metastatic prostatic carcinoma

Frederick J Meyers, S. J. Denardo, D. Macey, Ralph W deVere White, M. Unger

Research output: Contribution to journal › Article › peer-review

Abstract

Indium-111-labeled monoclonal antibody directed against prostate-specific antigen was injected into ten patients with known prostatic carcinoma, nine with metastatic disease. The monoclonal antibody scan was compared to the standard technetium bone scan, and both were correlated to clinical status and to 2-year follow-up. The ratio of target-to-nontarget activity and pharmacokinetics of the radiolabeled antibody approach may be used for staging and may be developed as a therapeutic adjuvant.

Original language	English (US)
Pages (from-to)	209-220
Number of pages	12
Journal	Prostate
Volume	14
Issue number	3
State	Published - 1989

ASJC Scopus subject areas

Urology

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title = "Development of monoclonal antibody imaging of metastatic prostatic carcinoma",

abstract = "Indium-111-labeled monoclonal antibody directed against prostate-specific antigen was injected into ten patients with known prostatic carcinoma, nine with metastatic disease. The monoclonal antibody scan was compared to the standard technetium bone scan, and both were correlated to clinical status and to 2-year follow-up. The ratio of target-to-nontarget activity and pharmacokinetics of the radiolabeled antibody approach may be used for staging and may be developed as a therapeutic adjuvant.",

author = "Meyers, {Frederick J} and Denardo, {S. J.} and D. Macey and {deVere White}, {Ralph W} and M. Unger",

year = "1989",

language = "English (US)",

volume = "14",

pages = "209--220",

journal = "Prostate",

issn = "0270-4137",

publisher = "Wiley-Liss Inc.",

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AU - Meyers, Frederick J

AU - Denardo, S. J.

AU - Macey, D.

AU - deVere White, Ralph W

AU - Unger, M.

PY - 1989

Y1 - 1989

N2 - Indium-111-labeled monoclonal antibody directed against prostate-specific antigen was injected into ten patients with known prostatic carcinoma, nine with metastatic disease. The monoclonal antibody scan was compared to the standard technetium bone scan, and both were correlated to clinical status and to 2-year follow-up. The ratio of target-to-nontarget activity and pharmacokinetics of the radiolabeled antibody approach may be used for staging and may be developed as a therapeutic adjuvant.

AB - Indium-111-labeled monoclonal antibody directed against prostate-specific antigen was injected into ten patients with known prostatic carcinoma, nine with metastatic disease. The monoclonal antibody scan was compared to the standard technetium bone scan, and both were correlated to clinical status and to 2-year follow-up. The ratio of target-to-nontarget activity and pharmacokinetics of the radiolabeled antibody approach may be used for staging and may be developed as a therapeutic adjuvant.

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