Development of larval schistosoma japonicum blocked in oncomelania hupensis by pre-infection with larval exorchis Sp.

Chong Ti Tang, Ming Ke Lu, Yue Guo, Yi Nan Wang, Jin Yong Peng, Wei Bao Wu, Wen Hong Li, Bart C Weimer, Dong Chen

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Schistosomiasis continues to be a significant public health threat in the world. In the area of parasitic diseases, it is widely considered second only to malaria as a global health problem, with an incalculable drain on the economic resources of countries where it is endemic. Schistosoma japonicum is widespread in eastern and southeastern Asia, where the amphibious snail, Oncomelania hupensis, is the intermediate host. In the present study, we found that infection of O. hupensis with the mature eggs of another trematode, Exorchis sp., inhibited development of S. japonicum mother sporocysts in O. hupensis. Exorchis sp. commonly infects the edible fish Parasilurus asotus in China, but it is harmless to humans. This discovery provides an opportunity for possible biological control of S. japonicum infection and transmission. Additionally, it has the potential to substantially reduce the impact of the global S. japonicum that is independent of antihelminthic use. The mechanisms used by Exorchis sp. to inhibit infection by S. japonicum in the snail require further investigation.

Original languageEnglish (US)
Pages (from-to)1321-1325
Number of pages5
JournalJournal of Parasitology
Volume95
Issue number6
DOIs
StatePublished - Dec 2009

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ASJC Scopus subject areas

  • Parasitology
  • Ecology, Evolution, Behavior and Systematics
  • Medicine(all)

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