Development of Injectable Amniotic Membrane Matrix for Postmyocardial Infarction Tissue Repair

Jeffrey J.D. Henry, Lawrence Delrosario, Jun Fang, Sze Yue Wong, Qizhi Fang, Richard Sievers, Surya Kotha, Aijun Wang, Diana Farmer, Praneeth Janaswamy, Randall J. Lee, Song Li

Research output: Contribution to journalArticle

Abstract

Ischemic heart disease represents the leading cause of death worldwide. Heart failure following myocardial infarction (MI) is associated with severe fibrosis formation and cardiac remodeling. Recently, injectable hydrogels have emerged as a promising approach to repair the infarcted heart and improve heart function through minimally invasive administration. Here, a novel injectable human amniotic membrane (hAM) matrix is developed to enhance cardiac regeneration following MI. Human amniotic membrane is isolated from human placenta and engineered to be a thermoresponsive, injectable gel around body temperature. Ultrasound-guided injection of hAM matrix into rat MI hearts significantly improves cardiac contractility, as measured by ejection fraction (EF), and decrease fibrosis. The results of this study demonstrate the feasibility of engineering as an injectable hAM matrix and its efficacy in attenuating degenerative changes in cardiac function following MI, which may have broad applications in tissue regeneration.

Original languageEnglish (US)
Article number1900544
JournalAdvanced Healthcare Materials
DOIs
StateAccepted/In press - Jan 1 2019

Keywords

  • amniotic membranes
  • decellularization
  • hydrogels
  • myocardial infarctions

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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  • Cite this

    Henry, J. J. D., Delrosario, L., Fang, J., Wong, S. Y., Fang, Q., Sievers, R., Kotha, S., Wang, A., Farmer, D., Janaswamy, P., Lee, R. J., & Li, S. (Accepted/In press). Development of Injectable Amniotic Membrane Matrix for Postmyocardial Infarction Tissue Repair. Advanced Healthcare Materials, [1900544]. https://doi.org/10.1002/adhm.201900544