Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain

Regina L. Faulkner, Mi Hyeon Jang, Xiao Bo Liu, Xin Duan, Kurt A. Sailor, Ju Young Kim, Shaoyu Ge, Edward G. Jones, Guo Li Ming, Hongjun Song, Hwai-Jong Cheng

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

New neurons are continuously generated in restricted regions of the adult mammalian brain. Although these adult-born neurons have been shown to receive synaptic inputs, little is known about their synaptic outputs. Using retrovirus-mediated birth-dating and labeling in combination with serial section electron microscopic reconstruction, we report that mossy fiber en passant boutons of adult-born dentate granule cells form initial synaptic contacts with CA3 pyramidal cells within 2 weeks after their birth and reach morphologic maturity within 8 weeks in the adult hippocampus. Knockdown of Disrupted-in-Schizophrenia-1 (DISC1) in newborn granule cells leads to defects in axonal targeting and development of synaptic outputs in the adult brain. Together with previous reports of synaptic inputs, these results demonstrate that adult-born neurons are fully integrated into the existing neuronal circuitry. Our results also indicate a role for DISC1 in presynaptic development and may have implications for the etiology of schizophrenia and related mental disorders.

Original languageEnglish (US)
Pages (from-to)14157-14162
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume105
Issue number37
DOIs
StatePublished - Sep 16 2008

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Hippocampal Mossy Fibers
Schizophrenia
Neurons
Brain
Parturition
Pyramidal Cells
Retroviridae
Mental Disorders
Hippocampus
Electrons

Keywords

  • Adult neurogenesis
  • Axon guidance
  • DISC1
  • Hippocampus
  • Synaptogenesis

ASJC Scopus subject areas

  • General

Cite this

Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain. / Faulkner, Regina L.; Jang, Mi Hyeon; Liu, Xiao Bo; Duan, Xin; Sailor, Kurt A.; Kim, Ju Young; Ge, Shaoyu; Jones, Edward G.; Ming, Guo Li; Song, Hongjun; Cheng, Hwai-Jong.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 37, 16.09.2008, p. 14157-14162.

Research output: Contribution to journalArticle

Faulkner, RL, Jang, MH, Liu, XB, Duan, X, Sailor, KA, Kim, JY, Ge, S, Jones, EG, Ming, GL, Song, H & Cheng, H-J 2008, 'Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain', Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 37, pp. 14157-14162. https://doi.org/10.1073/pnas.0806658105
Faulkner, Regina L. ; Jang, Mi Hyeon ; Liu, Xiao Bo ; Duan, Xin ; Sailor, Kurt A. ; Kim, Ju Young ; Ge, Shaoyu ; Jones, Edward G. ; Ming, Guo Li ; Song, Hongjun ; Cheng, Hwai-Jong. / Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain. In: Proceedings of the National Academy of Sciences of the United States of America. 2008 ; Vol. 105, No. 37. pp. 14157-14162.
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