Development of caspofungin resistance following prolonged therapy for invasive candidiasis secondary to Candida glabrata infection

George Richard Thompson, Nathan P. Wiederhold, Ana C. Vallor, Nyria C. Villareal, James S. Lewis, Thomas F. Patterson

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

We report a case of Candida glabrata invasive candidiasis that developed reduced susceptibility to caspofungin during prolonged therapy. Pre- and posttreatment isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed an F659V substitution within the FKS2 region of the glucan synthase complex.

Original languageEnglish (US)
Pages (from-to)3783-3785
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume52
Issue number10
DOIs
StatePublished - Oct 2008
Externally publishedYes

Fingerprint

caspofungin
Invasive Candidiasis
Echinocandins
Candida glabrata
Infection
Therapeutics
glucan synthase

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Development of caspofungin resistance following prolonged therapy for invasive candidiasis secondary to Candida glabrata infection. / Thompson, George Richard; Wiederhold, Nathan P.; Vallor, Ana C.; Villareal, Nyria C.; Lewis, James S.; Patterson, Thomas F.

In: Antimicrobial Agents and Chemotherapy, Vol. 52, No. 10, 10.2008, p. 3783-3785.

Research output: Contribution to journalArticle

Thompson, George Richard ; Wiederhold, Nathan P. ; Vallor, Ana C. ; Villareal, Nyria C. ; Lewis, James S. ; Patterson, Thomas F. / Development of caspofungin resistance following prolonged therapy for invasive candidiasis secondary to Candida glabrata infection. In: Antimicrobial Agents and Chemotherapy. 2008 ; Vol. 52, No. 10. pp. 3783-3785.
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