Development of breeding populations of rhesus macaques (Macaca mulatta) that are specific pathogen-free for rhesus cytomegalovirus

Peter A Barry, Lisa Strelow

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Development of breeding colonies of rhesus macaques (Macaca mulatta) that are specific pathogen-free (SPF) for rhesus cytomegalovirus (RhCMV) is relatively straightforward and requires few modifications from current SPF programs. Infants separated from the dam at or within a few days of birth and cohoused with similarly treated animals remain RhCMV seronegative indefinitely, provided they are never directly or indirectly exposed to a RhCMV-infected monkey. By systematically cohousing seronegative animals into larger social cohorts, breeding populations of animals SPF for RhCMV can be established. The additional costs involved in expanding the current definition of SPF status to include RhCMV are incremental compared with the money already being spent on existing SPF efforts. Moreover, the large increase in research opportunities available for RhCMV-free animals arguably would far exceed the development costs. Potential new areas of research and further expansion of existing research efforts involving these newly defined SPF animals would have direct implications for improvements in human health.

Original languageEnglish (US)
Pages (from-to)43-46
Number of pages4
JournalComparative Medicine
Volume58
Issue number1
StatePublished - Feb 2008

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Specific Pathogen-Free Organisms
Cytomegalovirus
Pathogens
Macaca mulatta
Breeding
Animals
specific pathogen-free animals
pathogens
breeding
Population
Macacine herpesvirus 3
animals
Research
Costs and Cost Analysis
dams (mothers)
human health
Dams
Haplorhini
Costs
Health

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Development of breeding populations of rhesus macaques (Macaca mulatta) that are specific pathogen-free for rhesus cytomegalovirus. / Barry, Peter A; Strelow, Lisa.

In: Comparative Medicine, Vol. 58, No. 1, 02.2008, p. 43-46.

Research output: Contribution to journalArticle

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