Development of an endoluminal intestinal lengthening capsule

Rebecca Stark, Mohanchandra Panduranga, Gregory Carman, James C.Y. Dunn

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Purpose: Prior studies demonstrated the ability of a spring to lengthen intestinal segments. We made two innovations to this device. First, we employed a degradable capsule to control the deployment of the spring. Second, we decreased the spring force to allow slower expansion of the intestinal segment. Methods: Nitinol springs with varying forces were compressed and placed in gelatin capsules. These capsules were coated with a degradable polymer and were placed in isolated segments of rat jejunum. Serial x-rays were used to determine the rate of spring expansion. Retrieved jejunal segments were analyzed histologically. Results: Using the polymer-coated capsule, the spring was reliably deployed between 24 and 48 hours. Intestinal segments were lengthened from 1.0 cm to 3.6 cm after 14 days. The optimal spring for the gradual expansion of jejunal segments had a spring constant of 0.0010 N/mm. Villus height was preserved, but crypt depth was significantly greater in the lengthened intestine. Conclusion: Use of a low-force spring resulted in a nearly four-fold lengthening of jejunal segments. The use of a polymer-coated capsule provided a reliable way to control the timing of spring deployment. This capsule may be useful for the endoscopic placement of the spring in patients with short bowel syndrome.

Original languageEnglish (US)
Pages (from-to)136-141
Number of pages6
JournalJournal of Pediatric Surgery
Volume47
Issue number1
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Fingerprint

Capsules
Polymers
Short Bowel Syndrome
Jejunum
Gelatin
Intestines
X-Rays
Equipment and Supplies

Keywords

  • Bowel lengthening
  • Distraction enterogenesis
  • Mechanical enterogenesis
  • Short bowel syndrome

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Development of an endoluminal intestinal lengthening capsule. / Stark, Rebecca; Panduranga, Mohanchandra; Carman, Gregory; Dunn, James C.Y.

In: Journal of Pediatric Surgery, Vol. 47, No. 1, 01.01.2012, p. 136-141.

Research output: Contribution to journalArticle

Stark, Rebecca ; Panduranga, Mohanchandra ; Carman, Gregory ; Dunn, James C.Y. / Development of an endoluminal intestinal lengthening capsule. In: Journal of Pediatric Surgery. 2012 ; Vol. 47, No. 1. pp. 136-141.
@article{64523fa8583047b49cec078c13cf953b,
title = "Development of an endoluminal intestinal lengthening capsule",
abstract = "Purpose: Prior studies demonstrated the ability of a spring to lengthen intestinal segments. We made two innovations to this device. First, we employed a degradable capsule to control the deployment of the spring. Second, we decreased the spring force to allow slower expansion of the intestinal segment. Methods: Nitinol springs with varying forces were compressed and placed in gelatin capsules. These capsules were coated with a degradable polymer and were placed in isolated segments of rat jejunum. Serial x-rays were used to determine the rate of spring expansion. Retrieved jejunal segments were analyzed histologically. Results: Using the polymer-coated capsule, the spring was reliably deployed between 24 and 48 hours. Intestinal segments were lengthened from 1.0 cm to 3.6 cm after 14 days. The optimal spring for the gradual expansion of jejunal segments had a spring constant of 0.0010 N/mm. Villus height was preserved, but crypt depth was significantly greater in the lengthened intestine. Conclusion: Use of a low-force spring resulted in a nearly four-fold lengthening of jejunal segments. The use of a polymer-coated capsule provided a reliable way to control the timing of spring deployment. This capsule may be useful for the endoscopic placement of the spring in patients with short bowel syndrome.",
keywords = "Bowel lengthening, Distraction enterogenesis, Mechanical enterogenesis, Short bowel syndrome",
author = "Rebecca Stark and Mohanchandra Panduranga and Gregory Carman and Dunn, {James C.Y.}",
year = "2012",
month = "1",
day = "1",
doi = "10.1016/j.jpedsurg.2011.10.031",
language = "English (US)",
volume = "47",
pages = "136--141",
journal = "Journal of Pediatric Surgery",
issn = "0022-3468",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Development of an endoluminal intestinal lengthening capsule

AU - Stark, Rebecca

AU - Panduranga, Mohanchandra

AU - Carman, Gregory

AU - Dunn, James C.Y.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Purpose: Prior studies demonstrated the ability of a spring to lengthen intestinal segments. We made two innovations to this device. First, we employed a degradable capsule to control the deployment of the spring. Second, we decreased the spring force to allow slower expansion of the intestinal segment. Methods: Nitinol springs with varying forces were compressed and placed in gelatin capsules. These capsules were coated with a degradable polymer and were placed in isolated segments of rat jejunum. Serial x-rays were used to determine the rate of spring expansion. Retrieved jejunal segments were analyzed histologically. Results: Using the polymer-coated capsule, the spring was reliably deployed between 24 and 48 hours. Intestinal segments were lengthened from 1.0 cm to 3.6 cm after 14 days. The optimal spring for the gradual expansion of jejunal segments had a spring constant of 0.0010 N/mm. Villus height was preserved, but crypt depth was significantly greater in the lengthened intestine. Conclusion: Use of a low-force spring resulted in a nearly four-fold lengthening of jejunal segments. The use of a polymer-coated capsule provided a reliable way to control the timing of spring deployment. This capsule may be useful for the endoscopic placement of the spring in patients with short bowel syndrome.

AB - Purpose: Prior studies demonstrated the ability of a spring to lengthen intestinal segments. We made two innovations to this device. First, we employed a degradable capsule to control the deployment of the spring. Second, we decreased the spring force to allow slower expansion of the intestinal segment. Methods: Nitinol springs with varying forces were compressed and placed in gelatin capsules. These capsules were coated with a degradable polymer and were placed in isolated segments of rat jejunum. Serial x-rays were used to determine the rate of spring expansion. Retrieved jejunal segments were analyzed histologically. Results: Using the polymer-coated capsule, the spring was reliably deployed between 24 and 48 hours. Intestinal segments were lengthened from 1.0 cm to 3.6 cm after 14 days. The optimal spring for the gradual expansion of jejunal segments had a spring constant of 0.0010 N/mm. Villus height was preserved, but crypt depth was significantly greater in the lengthened intestine. Conclusion: Use of a low-force spring resulted in a nearly four-fold lengthening of jejunal segments. The use of a polymer-coated capsule provided a reliable way to control the timing of spring deployment. This capsule may be useful for the endoscopic placement of the spring in patients with short bowel syndrome.

KW - Bowel lengthening

KW - Distraction enterogenesis

KW - Mechanical enterogenesis

KW - Short bowel syndrome

UR - http://www.scopus.com/inward/record.url?scp=84855834433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855834433&partnerID=8YFLogxK

U2 - 10.1016/j.jpedsurg.2011.10.031

DO - 10.1016/j.jpedsurg.2011.10.031

M3 - Article

C2 - 22244406

AN - SCOPUS:84855834433

VL - 47

SP - 136

EP - 141

JO - Journal of Pediatric Surgery

JF - Journal of Pediatric Surgery

SN - 0022-3468

IS - 1

ER -