Development of a spherically focused phased array transducer for ultrasonic image-guided hyperthermia

Jingfei Liu, Josquin Foiret, Douglas N. Stephens, Olivier Le Baron, Katherine W. Ferrara

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A 1.5 MHz prolate spheroidal therapeutic array with 128 circular elements was designed to accommodate standard imaging arrays for ultrasonic image-guided hyperthermia. The implementation of this dual-array system integrates real-time therapeutic and imaging functions with a single ultrasound system (Vantage 256, Verasonics). To facilitate applications involving small animal imaging and therapy the array was designed to have a beam depth of field smaller than 3.5 mm and to electronically steer over distances greater than 1 cm in both the axial and lateral directions. In order to achieve the required f number of 0.69, 1-3 piezocomposite modules were mated within the transducer housing. The performance of the prototype array was experimentally evaluated with excellent agreement with numerical simulation. A focal volume (2.70 mm (axial)x 0.65 mm (transverse)x 0.35 mm (transverse)) defined by the -6 dB focal intensity was obtained to address the dimensions needed for small animal therapy. An electronic beam steering range defined by the -3 dB focal peak intensity (17 mm (axial)x 14 mm (transverse)x 12 mm (transverse)) and -8 dB lateral grating lobes (24 mm (axial)x 18 mm (transverse)x 16 mm (transverse)) was achieved. The combined testing of imaging and therapeutic functions confirmed well-controlled local heating generation and imaging in a tissue mimicking phantom. This dual-array implementation offers a practical means to achieve hyperthermia and ablation in small animal models and can be incorporated within protocols for ultrasound-mediated drug delivery.

Original languageEnglish (US)
Article number5275
JournalPhysics in Medicine and Biology
Volume61
Issue number14
DOIs
StatePublished - Jun 29 2016

Keywords

  • focused ultrasound therapy
  • phased array transducer
  • ultrasonic image-guided hyperthermia
  • ultrasound hyperthermia

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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