Development of a rhesus monkey lung geometry model and application to particle deposition in comparison to humans

Bahman Asgharian, Owen Price, Gene McClellan, Rick Corley, Daniel R. Einstein, Richard E. Jacob, Jack Harkema, Stephan A. Carey, Edward S Schelegle, Dallas Hyde, Julia S. Kimbell, Frederick J. Miller

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The exposure-dose-response characterization of an inhalation hazard established in an animal species needs to be translated to an equivalent characterization in humans relative to comparable doses or exposure scenarios. Here, the first geometry model of the conducting airways for rhesus monkeys is developed based upon CT images of the conducting airways of a 6-month-old male, rhesus monkey. An algorithm was developed for adding the alveolar region airways using published rhesus morphometric data. The resultant lung geometry model can be used in mechanistic particle or gaseous dosimetry models. Such dosimetry models require estimates of the upper respiratory tract volume of the animal and the functional residual capacity, as well as of the tidal volume and breathing frequency of the animal. The relationship of these variables to rhesus monkeys of differing body weights was established by synthesizing and modeling published data as well as modeling pulmonary function measurements on 121 rhesus control animals. Deposition patterns of particles up to 10 m in size were examined for endotracheal and and up to 5 m for spontaneous breathing in infant and young adult monkeys and compared to those for humans. Deposition fraction of respirable size particles was found to be higher in the conducting airways of infant and young adult rhesus monkeys compared to humans. Due to the filtering effect of the conducting airways, pulmonary deposition in rhesus monkeys was lower than that in humans. Future research areas are identified that would either allow replacing assumptions or improving the newly developed lung model.

Original languageEnglish (US)
Pages (from-to)869-899
Number of pages31
JournalInhalation Toxicology
Volume24
Issue number13
DOIs
StatePublished - Nov 2012

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Macaca mulatta
Animals
Lung
Geometry
Dosimetry
Young Adult
Respiration
Functional Residual Capacity
Tidal Volume
Particle Size
Respiratory System
Inhalation
Haplorhini
Data structures
Hazards
Particle size
Body Weight

Keywords

  • Breathing parameters
  • Deposition modeling
  • Humans
  • Lung geometry
  • Particles
  • Rhesus monkeys

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Asgharian, B., Price, O., McClellan, G., Corley, R., Einstein, D. R., Jacob, R. E., ... Miller, F. J. (2012). Development of a rhesus monkey lung geometry model and application to particle deposition in comparison to humans. Inhalation Toxicology, 24(13), 869-899. https://doi.org/10.3109/08958378.2012.725782

Development of a rhesus monkey lung geometry model and application to particle deposition in comparison to humans. / Asgharian, Bahman; Price, Owen; McClellan, Gene; Corley, Rick; Einstein, Daniel R.; Jacob, Richard E.; Harkema, Jack; Carey, Stephan A.; Schelegle, Edward S; Hyde, Dallas; Kimbell, Julia S.; Miller, Frederick J.

In: Inhalation Toxicology, Vol. 24, No. 13, 11.2012, p. 869-899.

Research output: Contribution to journalArticle

Asgharian, B, Price, O, McClellan, G, Corley, R, Einstein, DR, Jacob, RE, Harkema, J, Carey, SA, Schelegle, ES, Hyde, D, Kimbell, JS & Miller, FJ 2012, 'Development of a rhesus monkey lung geometry model and application to particle deposition in comparison to humans', Inhalation Toxicology, vol. 24, no. 13, pp. 869-899. https://doi.org/10.3109/08958378.2012.725782
Asgharian, Bahman ; Price, Owen ; McClellan, Gene ; Corley, Rick ; Einstein, Daniel R. ; Jacob, Richard E. ; Harkema, Jack ; Carey, Stephan A. ; Schelegle, Edward S ; Hyde, Dallas ; Kimbell, Julia S. ; Miller, Frederick J. / Development of a rhesus monkey lung geometry model and application to particle deposition in comparison to humans. In: Inhalation Toxicology. 2012 ; Vol. 24, No. 13. pp. 869-899.
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