Abstract
Seizures, particularly multiple episodes and/or status epilepticus (SE) are prevalent in pediatric patients. Pediatric SE is associated with brain changes that have been hypothesized to contribute to the onset of temporal lobe epilepsy (TLE). In order to gain insight into the effects of seizures on the immature brain and the risk for later TLE, we have developed a model of limbic SE in the pigtailed macaque monkey. In separate studies, bicuculline methiodide or a bicuculline 'cocktail' was infused into three regions of the brain (area tempestas, hippocampus, entorhinal cortex) to induce seizures. Measures included MRI, electrophysiology, behavior and morphology. Our results suggest that monkey models of SE may provide useful tools for understanding the effects of prolonged seizures during infancy and the origins of TLE in humans.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 352-364 |
| Number of pages | 13 |
| Journal | Developmental Neuroscience |
| Volume | 21 |
| Issue number | 3-5 |
| State | Published - May 1999 |
| Externally published | Yes |
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Keywords
- Monkey
- Status epilepticus, pediatric
- Temporal lobe epilepsy
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Development of a model of status epilepticus in pigtailed macaque infant monkeys. / Gunderson, Virginia M.; Dubach, Mark; Szot, Patricia; Born, Donald E.; Wenzel, H. Jurgen; Maravilla, Kenneth R.; Zierath, Dannielle K.; Robbins, Carol A.; Schwartzkroin, Philip A.
In: Developmental Neuroscience, Vol. 21, No. 3-5, 05.1999, p. 352-364.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Development of a model of status epilepticus in pigtailed macaque infant monkeys
AU - Gunderson, Virginia M.
AU - Dubach, Mark
AU - Szot, Patricia
AU - Born, Donald E.
AU - Wenzel, H. Jurgen
AU - Maravilla, Kenneth R.
AU - Zierath, Dannielle K.
AU - Robbins, Carol A.
AU - Schwartzkroin, Philip A
PY - 1999/5
Y1 - 1999/5
N2 - Seizures, particularly multiple episodes and/or status epilepticus (SE) are prevalent in pediatric patients. Pediatric SE is associated with brain changes that have been hypothesized to contribute to the onset of temporal lobe epilepsy (TLE). In order to gain insight into the effects of seizures on the immature brain and the risk for later TLE, we have developed a model of limbic SE in the pigtailed macaque monkey. In separate studies, bicuculline methiodide or a bicuculline 'cocktail' was infused into three regions of the brain (area tempestas, hippocampus, entorhinal cortex) to induce seizures. Measures included MRI, electrophysiology, behavior and morphology. Our results suggest that monkey models of SE may provide useful tools for understanding the effects of prolonged seizures during infancy and the origins of TLE in humans.
AB - Seizures, particularly multiple episodes and/or status epilepticus (SE) are prevalent in pediatric patients. Pediatric SE is associated with brain changes that have been hypothesized to contribute to the onset of temporal lobe epilepsy (TLE). In order to gain insight into the effects of seizures on the immature brain and the risk for later TLE, we have developed a model of limbic SE in the pigtailed macaque monkey. In separate studies, bicuculline methiodide or a bicuculline 'cocktail' was infused into three regions of the brain (area tempestas, hippocampus, entorhinal cortex) to induce seizures. Measures included MRI, electrophysiology, behavior and morphology. Our results suggest that monkey models of SE may provide useful tools for understanding the effects of prolonged seizures during infancy and the origins of TLE in humans.
KW - Monkey
KW - Status epilepticus, pediatric
KW - Temporal lobe epilepsy
UR - http://www.scopus.com/inward/record.url?scp=0032713184&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032713184&partnerID=8YFLogxK
M3 - Article
VL - 21
SP - 352
EP - 364
JO - Developmental Neuroscience
JF - Developmental Neuroscience
SN - 0378-5866
IS - 3-5
ER -