Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection

Anna Z. Wec; Zachary A. Bornholdt; Shihua He; Andrew S. Herbert; Eileen Goodwin; Ariel S. Wirchnianski; Bronwyn M. Gunn; Zirui Zhang; Wenjun Zhu; Guodong Liu; Dafna M. Abelson; Crystal L. Moyer; Rohit K. Jangra; Rebekah M. James; Russell R. Bakken; Natasha Bohorova; Ognian Bohorov; Do H. Kim; Michael H. Pauly; Jesus Velasco; Robert H. Bortz; Kevin J. Whaley; Tracey Goldstein; Simon J. Anthony; Galit Alter; Laura M. Walker; John M. Dye; Larry Zeitlin; Xiangguo Qiu; Kartik Chandran

doi:10.1016/j.chom.2018.12.004

Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection

Anna Z. Wec, Zachary A. Bornholdt, Shihua He, Andrew S. Herbert, Eileen Goodwin, Ariel S. Wirchnianski, Bronwyn M. Gunn, Zirui Zhang, Wenjun Zhu, Guodong Liu, Dafna M. Abelson, Crystal L. Moyer, Rohit K. Jangra, Rebekah M. James, Russell R. Bakken, Natasha Bohorova, Ognian Bohorov, Do H. Kim, Michael H. Pauly, Jesus VelascoRobert H. Bortz, Kevin J. Whaley, Tracey Goldstein, Simon J. Anthony, Galit Alter, Laura M. Walker, John M. Dye, Larry Zeitlin, Xiangguo Qiu, Kartik Chandran

School of Veterinary Medicine

Research output: Contribution to journal › Article

14 Scopus citations

Abstract

Broadly protective therapies against filoviruses are urgently needed. Wec et al. advance a cocktail of two human mAbs as a candidate pan-ebolavirus therapeutic. The mAbs were selected for antiviral potency and breadth, engineered to enhance breadth and Fc effector functions, and tested against multiple ebolaviruses in guinea pig models of lethal challenge.

Original language	English (US)
Pages (from-to)	39-48.e5
Journal	Cell Host and Microbe
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/j.chom.2018.12.004
State	Published - Jan 9 2019

Keywords

antibody cocktail
antibody engineering
antiviral drug
broadly neutralizing antibodies
Ebola glycoprotein
Ebola virus
ebolavirus
filovirus
human monoclonal antibodies
immunotherapy

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

Access to Document

10.1016/j.chom.2018.12.004

Fingerprint Dive into the research topics of 'Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection'. Together they form a unique fingerprint.

Cite this

Wec, A. Z., Bornholdt, Z. A., He, S., Herbert, A. S., Goodwin, E., Wirchnianski, A. S., Gunn, B. M., Zhang, Z., Zhu, W., Liu, G., Abelson, D. M., Moyer, C. L., Jangra, R. K., James, R. M., Bakken, R. R., Bohorova, N., Bohorov, O., Kim, D. H., Pauly, M. H., ... Chandran, K. (2019). Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection. Cell Host and Microbe, 25(1), 39-48.e5. https://doi.org/10.1016/j.chom.2018.12.004

Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection. / Wec, Anna Z.; Bornholdt, Zachary A.; He, Shihua; Herbert, Andrew S.; Goodwin, Eileen; Wirchnianski, Ariel S.; Gunn, Bronwyn M.; Zhang, Zirui; Zhu, Wenjun; Liu, Guodong; Abelson, Dafna M.; Moyer, Crystal L.; Jangra, Rohit K.; James, Rebekah M.; Bakken, Russell R.; Bohorova, Natasha; Bohorov, Ognian; Kim, Do H.; Pauly, Michael H.; Velasco, Jesus; Bortz, Robert H.; Whaley, Kevin J.; Goldstein, Tracey; Anthony, Simon J.; Alter, Galit; Walker, Laura M.; Dye, John M.; Zeitlin, Larry; Qiu, Xiangguo; Chandran, Kartik.

In: Cell Host and Microbe, Vol. 25, No. 1, 09.01.2019, p. 39-48.e5.

Research output: Contribution to journal › Article

Wec, AZ, Bornholdt, ZA, He, S, Herbert, AS, Goodwin, E, Wirchnianski, AS, Gunn, BM, Zhang, Z, Zhu, W, Liu, G, Abelson, DM, Moyer, CL, Jangra, RK, James, RM, Bakken, RR, Bohorova, N, Bohorov, O, Kim, DH, Pauly, MH, Velasco, J, Bortz, RH, Whaley, KJ, Goldstein, T, Anthony, SJ, Alter, G, Walker, LM, Dye, JM, Zeitlin, L, Qiu, X & Chandran, K 2019, 'Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection', Cell Host and Microbe, vol. 25, no. 1, pp. 39-48.e5. https://doi.org/10.1016/j.chom.2018.12.004

Wec, Anna Z. ; Bornholdt, Zachary A. ; He, Shihua ; Herbert, Andrew S. ; Goodwin, Eileen ; Wirchnianski, Ariel S. ; Gunn, Bronwyn M. ; Zhang, Zirui ; Zhu, Wenjun ; Liu, Guodong ; Abelson, Dafna M. ; Moyer, Crystal L. ; Jangra, Rohit K. ; James, Rebekah M. ; Bakken, Russell R. ; Bohorova, Natasha ; Bohorov, Ognian ; Kim, Do H. ; Pauly, Michael H. ; Velasco, Jesus ; Bortz, Robert H. ; Whaley, Kevin J. ; Goldstein, Tracey ; Anthony, Simon J. ; Alter, Galit ; Walker, Laura M. ; Dye, John M. ; Zeitlin, Larry ; Qiu, Xiangguo ; Chandran, Kartik. / Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection. In: Cell Host and Microbe. 2019 ; Vol. 25, No. 1. pp. 39-48.e5.

@article{c0acd2e9b69242859686c08e52b02d8a,

title = "Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection",

abstract = "Broadly protective therapies against filoviruses are urgently needed. Wec et al. advance a cocktail of two human mAbs as a candidate pan-ebolavirus therapeutic. The mAbs were selected for antiviral potency and breadth, engineered to enhance breadth and Fc effector functions, and tested against multiple ebolaviruses in guinea pig models of lethal challenge.",

keywords = "antibody cocktail, antibody engineering, antiviral drug, broadly neutralizing antibodies, Ebola glycoprotein, Ebola virus, ebolavirus, filovirus, human monoclonal antibodies, immunotherapy",

author = "Wec, {Anna Z.} and Bornholdt, {Zachary A.} and Shihua He and Herbert, {Andrew S.} and Eileen Goodwin and Wirchnianski, {Ariel S.} and Gunn, {Bronwyn M.} and Zirui Zhang and Wenjun Zhu and Guodong Liu and Abelson, {Dafna M.} and Moyer, {Crystal L.} and Jangra, {Rohit K.} and James, {Rebekah M.} and Bakken, {Russell R.} and Natasha Bohorova and Ognian Bohorov and Kim, {Do H.} and Pauly, {Michael H.} and Jesus Velasco and Bortz, {Robert H.} and Whaley, {Kevin J.} and Tracey Goldstein and Anthony, {Simon J.} and Galit Alter and Walker, {Laura M.} and Dye, {John M.} and Larry Zeitlin and Xiangguo Qiu and Kartik Chandran",

year = "2019",

month = jan,

day = "9",

doi = "10.1016/j.chom.2018.12.004",

language = "English (US)",

volume = "25",

pages = "39--48.e5",

journal = "Cell Host and Microbe",

issn = "1931-3128",

publisher = "Cell Press",

number = "1",

}

TY - JOUR

T1 - Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection

AU - Wec, Anna Z.

AU - Bornholdt, Zachary A.

AU - He, Shihua

AU - Herbert, Andrew S.

AU - Goodwin, Eileen

AU - Wirchnianski, Ariel S.

AU - Gunn, Bronwyn M.

AU - Zhang, Zirui

AU - Zhu, Wenjun

AU - Liu, Guodong

AU - Abelson, Dafna M.

AU - Moyer, Crystal L.

AU - Jangra, Rohit K.

AU - James, Rebekah M.

AU - Bakken, Russell R.

AU - Bohorova, Natasha

AU - Bohorov, Ognian

AU - Kim, Do H.

AU - Pauly, Michael H.

AU - Velasco, Jesus

AU - Bortz, Robert H.

AU - Whaley, Kevin J.

AU - Goldstein, Tracey

AU - Anthony, Simon J.

AU - Alter, Galit

AU - Walker, Laura M.

AU - Dye, John M.

AU - Zeitlin, Larry

AU - Qiu, Xiangguo

AU - Chandran, Kartik

PY - 2019/1/9

Y1 - 2019/1/9

N2 - Broadly protective therapies against filoviruses are urgently needed. Wec et al. advance a cocktail of two human mAbs as a candidate pan-ebolavirus therapeutic. The mAbs were selected for antiviral potency and breadth, engineered to enhance breadth and Fc effector functions, and tested against multiple ebolaviruses in guinea pig models of lethal challenge.

AB - Broadly protective therapies against filoviruses are urgently needed. Wec et al. advance a cocktail of two human mAbs as a candidate pan-ebolavirus therapeutic. The mAbs were selected for antiviral potency and breadth, engineered to enhance breadth and Fc effector functions, and tested against multiple ebolaviruses in guinea pig models of lethal challenge.

KW - antibody cocktail

KW - antibody engineering

KW - antiviral drug

KW - broadly neutralizing antibodies

KW - Ebola glycoprotein

KW - Ebola virus

KW - ebolavirus

KW - filovirus

KW - human monoclonal antibodies

KW - immunotherapy

UR - http://www.scopus.com/inward/record.url?scp=85058800693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058800693&partnerID=8YFLogxK

U2 - 10.1016/j.chom.2018.12.004

DO - 10.1016/j.chom.2018.12.004

M3 - Article

C2 - 30629917

AN - SCOPUS:85058800693

VL - 25

SP - 39-48.e5

JO - Cell Host and Microbe

JF - Cell Host and Microbe

SN - 1931-3128

IS - 1

ER -