Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection

Anna Z. Wec, Zachary A. Bornholdt, Shihua He, Andrew S. Herbert, Eileen Goodwin, Ariel S. Wirchnianski, Bronwyn M. Gunn, Zirui Zhang, Wenjun Zhu, Guodong Liu, Dafna M. Abelson, Crystal L. Moyer, Rohit K. Jangra, Rebekah M. James, Russell R. Bakken, Natasha Bohorova, Ognian Bohorov, Do H. Kim, Michael H. Pauly, Jesus VelascoRobert H. Bortz, Kevin J. Whaley, Tracey Goldstein, Simon J. Anthony, Galit Alter, Laura M. Walker, John M. Dye, Larry Zeitlin, Xiangguo Qiu, Kartik Chandran

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Broadly protective therapies against filoviruses are urgently needed. Wec et al. advance a cocktail of two human mAbs as a candidate pan-ebolavirus therapeutic. The mAbs were selected for antiviral potency and breadth, engineered to enhance breadth and Fc effector functions, and tested against multiple ebolaviruses in guinea pig models of lethal challenge.

Original languageEnglish (US)
Pages (from-to)39-48.e5
JournalCell Host and Microbe
Volume25
Issue number1
DOIs
StatePublished - Jan 9 2019

Keywords

  • antibody cocktail
  • antibody engineering
  • antiviral drug
  • broadly neutralizing antibodies
  • Ebola glycoprotein
  • Ebola virus
  • ebolavirus
  • filovirus
  • human monoclonal antibodies
  • immunotherapy

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

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  • Cite this

    Wec, A. Z., Bornholdt, Z. A., He, S., Herbert, A. S., Goodwin, E., Wirchnianski, A. S., Gunn, B. M., Zhang, Z., Zhu, W., Liu, G., Abelson, D. M., Moyer, C. L., Jangra, R. K., James, R. M., Bakken, R. R., Bohorova, N., Bohorov, O., Kim, D. H., Pauly, M. H., ... Chandran, K. (2019). Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection. Cell Host and Microbe, 25(1), 39-48.e5. https://doi.org/10.1016/j.chom.2018.12.004