Abstract
Broadly protective therapies against filoviruses are urgently needed. Wec et al. advance a cocktail of two human mAbs as a candidate pan-ebolavirus therapeutic. The mAbs were selected for antiviral potency and breadth, engineered to enhance breadth and Fc effector functions, and tested against multiple ebolaviruses in guinea pig models of lethal challenge.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 39-48.e5 |
| Journal | Cell Host and Microbe |
| Volume | 25 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 9 2019 |
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Keywords
- antibody cocktail
- antibody engineering
- antiviral drug
- broadly neutralizing antibodies
- Ebola glycoprotein
- Ebola virus
- ebolavirus
- filovirus
- human monoclonal antibodies
- immunotherapy
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Virology
Cite this
Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection. / Wec, Anna Z.; Bornholdt, Zachary A.; He, Shihua; Herbert, Andrew S.; Goodwin, Eileen; Wirchnianski, Ariel S.; Gunn, Bronwyn M.; Zhang, Zirui; Zhu, Wenjun; Liu, Guodong; Abelson, Dafna M.; Moyer, Crystal L.; Jangra, Rohit K.; James, Rebekah M.; Bakken, Russell R.; Bohorova, Natasha; Bohorov, Ognian; Kim, Do H.; Pauly, Michael H.; Velasco, Jesus; Bortz, Robert H.; Whaley, Kevin J.; Goldstein, Tracey; Anthony, Simon J.; Alter, Galit; Walker, Laura M.; Dye, John M.; Zeitlin, Larry; Qiu, Xiangguo; Chandran, Kartik.
In: Cell Host and Microbe, Vol. 25, No. 1, 09.01.2019, p. 39-48.e5.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection
AU - Wec, Anna Z.
AU - Bornholdt, Zachary A.
AU - He, Shihua
AU - Herbert, Andrew S.
AU - Goodwin, Eileen
AU - Wirchnianski, Ariel S.
AU - Gunn, Bronwyn M.
AU - Zhang, Zirui
AU - Zhu, Wenjun
AU - Liu, Guodong
AU - Abelson, Dafna M.
AU - Moyer, Crystal L.
AU - Jangra, Rohit K.
AU - James, Rebekah M.
AU - Bakken, Russell R.
AU - Bohorova, Natasha
AU - Bohorov, Ognian
AU - Kim, Do H.
AU - Pauly, Michael H.
AU - Velasco, Jesus
AU - Bortz, Robert H.
AU - Whaley, Kevin J.
AU - Goldstein, Tracey
AU - Anthony, Simon J.
AU - Alter, Galit
AU - Walker, Laura M.
AU - Dye, John M.
AU - Zeitlin, Larry
AU - Qiu, Xiangguo
AU - Chandran, Kartik
PY - 2019/1/9
Y1 - 2019/1/9
N2 - Broadly protective therapies against filoviruses are urgently needed. Wec et al. advance a cocktail of two human mAbs as a candidate pan-ebolavirus therapeutic. The mAbs were selected for antiviral potency and breadth, engineered to enhance breadth and Fc effector functions, and tested against multiple ebolaviruses in guinea pig models of lethal challenge.
AB - Broadly protective therapies against filoviruses are urgently needed. Wec et al. advance a cocktail of two human mAbs as a candidate pan-ebolavirus therapeutic. The mAbs were selected for antiviral potency and breadth, engineered to enhance breadth and Fc effector functions, and tested against multiple ebolaviruses in guinea pig models of lethal challenge.
KW - antibody cocktail
KW - antibody engineering
KW - antiviral drug
KW - broadly neutralizing antibodies
KW - Ebola glycoprotein
KW - Ebola virus
KW - ebolavirus
KW - filovirus
KW - human monoclonal antibodies
KW - immunotherapy
UR - http://www.scopus.com/inward/record.url?scp=85058800693&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058800693&partnerID=8YFLogxK
U2 - 10.1016/j.chom.2018.12.004
DO - 10.1016/j.chom.2018.12.004
M3 - Article
C2 - 30629917
AN - SCOPUS:85058800693
VL - 25
SP - 39-48.e5
JO - Cell Host and Microbe
JF - Cell Host and Microbe
SN - 1931-3128
IS - 1
ER -