Development, History, and Future of Automated Cell Counters

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Modern automated hematology instruments use either optical methods (light scatter), impedance-based methods based on the Coulter principle (changes in electrical current induced by blood cells flowing through an electrically charged opening), or a combination of both optical and impedance-based methods. Progressive improvement in these instruments has allowed the enumeration and evaluation of blood cells with great accuracy, precision, and speed at very low cost. Future directions of hematology instrumentation include the addition of new parameters and the development of point-of-care instrumentation. In the future, in-vivo analysis of blood cells may allow noninvasive and near-continuous measurements.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalClinics in Laboratory Medicine
Issue number1
StatePublished - Mar 1 2015


  • Automated cell counter
  • Blood
  • Electrical impedance counting
  • Flow cytometry
  • Hematology
  • Hemoglobin
  • Light scattering
  • Point of Care

ASJC Scopus subject areas

  • Biochemistry, medical
  • Clinical Biochemistry


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