Abstract
Background: A validated scale is needed for objective and reproducible comparisons of facial fine lines before and after treatment in practice and clinical studies. Objective: To describe the development and validation of the 5-point photonumeric Allergan Fine Lines Scale. Methods: The Allergan Fine Lines Scale was developed to include an assessment guide, verbal descriptors, morphed images, and real subject images for each scale grade. The clinical significance of a 1-point score difference was evaluated in a review of multiple image pairs representing varying differences in severity. Interrater and intrarater reliability was evaluated in a live subject validation study (N = 289) completed during 2 sessions occurring 3 weeks apart. Results: A score difference of ≥1 point was shown to reflect a clinically significant difference (mean [95% CI] absolute score difference, 1.06 [0.92-1.21] for clinically different image pairs and 0.50 [0.38-0.61] for not clinically different pairs). Intrarater agreement between the 2 live subject validation sessions was almost perfect (weighted kappa = 0.85). Interrater agreement was substantial during the second rating session (0.76, primary end point). Conclusion: The Allergan Fine Lines Scale is a validated and reliable scale for physician rating of severity of superficial fine lines.
| Original language | English (US) |
|---|---|
| Pages (from-to) | S227-S234 |
| Journal | Dermatologic Surgery |
| Volume | 42 |
| DOIs | |
| State | Published - 2016 |
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ASJC Scopus subject areas
- Surgery
- Dermatology
Cite this
Development and validation of a photonumeric scale for evaluation of facial fine lines. / Carruthers, Jean; Donofrio, Lisa; Hardas, Bhushan; Murphy, Diane K.; Jones, Derek; Carruthers, Alastair; Sykes, Jonathan M; Creutz, Lela; Marx, Ann; Dill, Sara.
In: Dermatologic Surgery, Vol. 42, 2016, p. S227-S234.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Development and validation of a photonumeric scale for evaluation of facial fine lines
AU - Carruthers, Jean
AU - Donofrio, Lisa
AU - Hardas, Bhushan
AU - Murphy, Diane K.
AU - Jones, Derek
AU - Carruthers, Alastair
AU - Sykes, Jonathan M
AU - Creutz, Lela
AU - Marx, Ann
AU - Dill, Sara
PY - 2016
Y1 - 2016
N2 - Background: A validated scale is needed for objective and reproducible comparisons of facial fine lines before and after treatment in practice and clinical studies. Objective: To describe the development and validation of the 5-point photonumeric Allergan Fine Lines Scale. Methods: The Allergan Fine Lines Scale was developed to include an assessment guide, verbal descriptors, morphed images, and real subject images for each scale grade. The clinical significance of a 1-point score difference was evaluated in a review of multiple image pairs representing varying differences in severity. Interrater and intrarater reliability was evaluated in a live subject validation study (N = 289) completed during 2 sessions occurring 3 weeks apart. Results: A score difference of ≥1 point was shown to reflect a clinically significant difference (mean [95% CI] absolute score difference, 1.06 [0.92-1.21] for clinically different image pairs and 0.50 [0.38-0.61] for not clinically different pairs). Intrarater agreement between the 2 live subject validation sessions was almost perfect (weighted kappa = 0.85). Interrater agreement was substantial during the second rating session (0.76, primary end point). Conclusion: The Allergan Fine Lines Scale is a validated and reliable scale for physician rating of severity of superficial fine lines.
AB - Background: A validated scale is needed for objective and reproducible comparisons of facial fine lines before and after treatment in practice and clinical studies. Objective: To describe the development and validation of the 5-point photonumeric Allergan Fine Lines Scale. Methods: The Allergan Fine Lines Scale was developed to include an assessment guide, verbal descriptors, morphed images, and real subject images for each scale grade. The clinical significance of a 1-point score difference was evaluated in a review of multiple image pairs representing varying differences in severity. Interrater and intrarater reliability was evaluated in a live subject validation study (N = 289) completed during 2 sessions occurring 3 weeks apart. Results: A score difference of ≥1 point was shown to reflect a clinically significant difference (mean [95% CI] absolute score difference, 1.06 [0.92-1.21] for clinically different image pairs and 0.50 [0.38-0.61] for not clinically different pairs). Intrarater agreement between the 2 live subject validation sessions was almost perfect (weighted kappa = 0.85). Interrater agreement was substantial during the second rating session (0.76, primary end point). Conclusion: The Allergan Fine Lines Scale is a validated and reliable scale for physician rating of severity of superficial fine lines.
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UR - http://www.scopus.com/inward/citedby.url?scp=85016004866&partnerID=8YFLogxK
U2 - 10.1097/DSS.0000000000000847
DO - 10.1097/DSS.0000000000000847
M3 - Article
VL - 42
SP - S227-S234
JO - Dermatologic Surgery
JF - Dermatologic Surgery
SN - 1076-0512
ER -