Development and validation of a photonumeric scale for evaluation of infraorbital hollows

Lisa Donofrio, Jean Carruthers, Bhushan Hardas, Diane K. Murphy, Derek Jones, Jonathan M Sykes, Alastair Carruthers, Lela Creutz, Ann Marx, Sara Dill

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: A validated scale is needed for objective and reproducible comparisons of infraorbital hollows (i.e., tear troughs) before and after treatment in practice and clinical studies. Objective: To describe the development and validation of the 5-point photonumeric Allergan Infraorbital Hollows Scale. Methods: The scale was developed to include an assessment guide, verbal descriptors, morphed images, and real subject images for each grade. The clinical significance of a 1-point score difference was evaluated in a review of image pairs representing varying differences in severity. Interrater and intrarater reliability was evaluated in a live-subject validation study (N = 297) completed during 2 sessions occurring 3 weeks apart. Results: A score difference of ≥1 point was shown to reflect a clinically significant difference (mean [95% confidence interval] absolute score difference, 0.90 [0.79-1.02] for clinically different image pairs and 0.33 [0.19-0.46] for not clinically different pairs). Intrarater agreement between the 2 validation sessions was substantial (mean weighted kappa = 0.79). Interrater agreement was substantial during the second rating session (0.70, primary end point). Conclusion: The Allergan Infraorbital Hollows Scale is a validated and reliable scale for physician rating severity of hollowing in the infraorbital area.

Original languageEnglish (US)
Pages (from-to)S251-S258
JournalDermatologic Surgery
Volume42
DOIs
StatePublished - 2016

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Validation Studies
Tears
Confidence Intervals
Physicians
Therapeutics
Clinical Studies

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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Development and validation of a photonumeric scale for evaluation of infraorbital hollows. / Donofrio, Lisa; Carruthers, Jean; Hardas, Bhushan; Murphy, Diane K.; Jones, Derek; Sykes, Jonathan M; Carruthers, Alastair; Creutz, Lela; Marx, Ann; Dill, Sara.

In: Dermatologic Surgery, Vol. 42, 2016, p. S251-S258.

Research output: Contribution to journalArticle

Donofrio, L, Carruthers, J, Hardas, B, Murphy, DK, Jones, D, Sykes, JM, Carruthers, A, Creutz, L, Marx, A & Dill, S 2016, 'Development and validation of a photonumeric scale for evaluation of infraorbital hollows', Dermatologic Surgery, vol. 42, pp. S251-S258. https://doi.org/10.1097/DSS.0000000000000856
Donofrio, Lisa ; Carruthers, Jean ; Hardas, Bhushan ; Murphy, Diane K. ; Jones, Derek ; Sykes, Jonathan M ; Carruthers, Alastair ; Creutz, Lela ; Marx, Ann ; Dill, Sara. / Development and validation of a photonumeric scale for evaluation of infraorbital hollows. In: Dermatologic Surgery. 2016 ; Vol. 42. pp. S251-S258.
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