Abstract
Background: A validated scale is needed for objective and reproducible comparisons of infraorbital hollows (i.e., tear troughs) before and after treatment in practice and clinical studies. Objective: To describe the development and validation of the 5-point photonumeric Allergan Infraorbital Hollows Scale. Methods: The scale was developed to include an assessment guide, verbal descriptors, morphed images, and real subject images for each grade. The clinical significance of a 1-point score difference was evaluated in a review of image pairs representing varying differences in severity. Interrater and intrarater reliability was evaluated in a live-subject validation study (N = 297) completed during 2 sessions occurring 3 weeks apart. Results: A score difference of ≥1 point was shown to reflect a clinically significant difference (mean [95% confidence interval] absolute score difference, 0.90 [0.79-1.02] for clinically different image pairs and 0.33 [0.19-0.46] for not clinically different pairs). Intrarater agreement between the 2 validation sessions was substantial (mean weighted kappa = 0.79). Interrater agreement was substantial during the second rating session (0.70, primary end point). Conclusion: The Allergan Infraorbital Hollows Scale is a validated and reliable scale for physician rating severity of hollowing in the infraorbital area.
| Original language | English (US) |
|---|---|
| Pages (from-to) | S251-S258 |
| Journal | Dermatologic Surgery |
| Volume | 42 |
| DOIs | |
| State | Published - 2016 |
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ASJC Scopus subject areas
- Surgery
- Dermatology
Cite this
Development and validation of a photonumeric scale for evaluation of infraorbital hollows. / Donofrio, Lisa; Carruthers, Jean; Hardas, Bhushan; Murphy, Diane K.; Jones, Derek; Sykes, Jonathan M; Carruthers, Alastair; Creutz, Lela; Marx, Ann; Dill, Sara.
In: Dermatologic Surgery, Vol. 42, 2016, p. S251-S258.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Development and validation of a photonumeric scale for evaluation of infraorbital hollows
AU - Donofrio, Lisa
AU - Carruthers, Jean
AU - Hardas, Bhushan
AU - Murphy, Diane K.
AU - Jones, Derek
AU - Sykes, Jonathan M
AU - Carruthers, Alastair
AU - Creutz, Lela
AU - Marx, Ann
AU - Dill, Sara
PY - 2016
Y1 - 2016
N2 - Background: A validated scale is needed for objective and reproducible comparisons of infraorbital hollows (i.e., tear troughs) before and after treatment in practice and clinical studies. Objective: To describe the development and validation of the 5-point photonumeric Allergan Infraorbital Hollows Scale. Methods: The scale was developed to include an assessment guide, verbal descriptors, morphed images, and real subject images for each grade. The clinical significance of a 1-point score difference was evaluated in a review of image pairs representing varying differences in severity. Interrater and intrarater reliability was evaluated in a live-subject validation study (N = 297) completed during 2 sessions occurring 3 weeks apart. Results: A score difference of ≥1 point was shown to reflect a clinically significant difference (mean [95% confidence interval] absolute score difference, 0.90 [0.79-1.02] for clinically different image pairs and 0.33 [0.19-0.46] for not clinically different pairs). Intrarater agreement between the 2 validation sessions was substantial (mean weighted kappa = 0.79). Interrater agreement was substantial during the second rating session (0.70, primary end point). Conclusion: The Allergan Infraorbital Hollows Scale is a validated and reliable scale for physician rating severity of hollowing in the infraorbital area.
AB - Background: A validated scale is needed for objective and reproducible comparisons of infraorbital hollows (i.e., tear troughs) before and after treatment in practice and clinical studies. Objective: To describe the development and validation of the 5-point photonumeric Allergan Infraorbital Hollows Scale. Methods: The scale was developed to include an assessment guide, verbal descriptors, morphed images, and real subject images for each grade. The clinical significance of a 1-point score difference was evaluated in a review of image pairs representing varying differences in severity. Interrater and intrarater reliability was evaluated in a live-subject validation study (N = 297) completed during 2 sessions occurring 3 weeks apart. Results: A score difference of ≥1 point was shown to reflect a clinically significant difference (mean [95% confidence interval] absolute score difference, 0.90 [0.79-1.02] for clinically different image pairs and 0.33 [0.19-0.46] for not clinically different pairs). Intrarater agreement between the 2 validation sessions was substantial (mean weighted kappa = 0.79). Interrater agreement was substantial during the second rating session (0.70, primary end point). Conclusion: The Allergan Infraorbital Hollows Scale is a validated and reliable scale for physician rating severity of hollowing in the infraorbital area.
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U2 - 10.1097/DSS.0000000000000856
DO - 10.1097/DSS.0000000000000856
M3 - Article
VL - 42
SP - S251-S258
JO - Dermatologic Surgery
JF - Dermatologic Surgery
SN - 1076-0512
ER -