Development and validation of a photonumeric scale for evaluation of volume deficit of the hand

Derek Jones, Lisa Donofrio, Bhushan Hardas, Diane K. Murphy, Jean Carruthers, Alastair Carruthers, Jonathan M Sykes, Lela Creutz, Ann Marx, Sara Dill

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background: A validated scale is needed for objective and reproducible comparisons of hand appearance before and after treatment in practice and clinical studies. Objective: To describe the development and validation of the 5-point photonumeric Allergan Hand Volume Deficit Scale. Methods: The scale was developed to include an assessment guide, verbal descriptors, morphed images, and real-subject images for each grade. The clinical significance of a 1-point score difference was evaluated in a review of image pairs representing varying differences in severity. Interrater and intrarater reliability was evaluated in a live-subject validation study (N = 296) completed during 2 sessions occurring 3 weeks apart. Results: A score difference of ≥1 point was shown to reflect a clinically significant difference (mean [95% confidence interval] absolute score difference, 1.12 [0.99-1.26] for clinically different image pairs and 0.45 [0.33-0.57] for not clinically different pairs). Intrarater agreement between the 2 validation sessions was almost perfect (mean weighted kappa = 0.83). Interrater agreement was almost perfect during the second session (0.82, primary end point). Conclusion: The Allergan Hand Volume Deficit Scale is a validated and reliable scale for physician rating of hand volume deficit.

Original languageEnglish (US)
Pages (from-to)S195-S202
JournalDermatologic Surgery
StatePublished - 2016

ASJC Scopus subject areas

  • Surgery
  • Dermatology


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