Development and spatial resolution characterization of a dedicated pulsed X-ray, cone-beam breast CT system

Peymon Gazi, Kai Yang, Geroge Burkett, John M Boone

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Dedicated breast CT (bCT) technology may be useful for patients with high risk of developing breast cancer. Previous studies have shown that bCT outperforms mammography in the visualization of mass lesions, however mammography is superior in identifying microcalcifications. The Breast Tomography Project at UC Davis has led to development of three dedicated breast CT scanners that produce high resolution, fully tomographic images, overcoming tissue superposition effects found in mammography while maintaining an equivalent radiation dose. Over 600 patients have been imaged in an ongoing clinical trial. The first patient scan was performed on the latest bCT scanner developed at UC Davis, called Cambria, on April 12, 2012. The main differences between Cambria and the previous scanners are in using a pulsed xray source (generator and tube) instead of continuous x-ray sources, and also in using the non-binning mode of the flatpanel fluoroscopic detector. The spatial resolution characteristics of the new scanner were investigated and the results show significant improvement in the overall MTF properties. Based on these results, it was concluded that using the pulsed x-ray tube, we were able to restore the MTF degradation caused by motion blurring effect that exists in previous generations of bCT. Moreover, MTF analysis shows that using the detector in the native acquisition mode (1 x 1) results in superior spatial resolution which will likely bring considerable improvement to the delineation of microcalcifications.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8668
DOIs
StatePublished - 2013
EventMedical Imaging 2013: Physics of Medical Imaging - Lake Buena Vista, FL, United States
Duration: Feb 11 2013Feb 14 2013

Other

OtherMedical Imaging 2013: Physics of Medical Imaging
CountryUnited States
CityLake Buena Vista, FL
Period2/11/132/14/13

Fingerprint

Mammography
Cone-Beam Computed Tomography
breast
Cones
cones
Breast
spatial resolution
X-Rays
X rays
scanners
modulation transfer function
Detectors
Calcinosis
x rays
Dosimetry
Tomography
Visualization
Tissue
Degradation
x ray tubes

Keywords

  • Cone-beam CT
  • MTF

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Gazi, P., Yang, K., Burkett, G., & Boone, J. M. (2013). Development and spatial resolution characterization of a dedicated pulsed X-ray, cone-beam breast CT system. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8668). [86681D] https://doi.org/10.1117/12.2007648

Development and spatial resolution characterization of a dedicated pulsed X-ray, cone-beam breast CT system. / Gazi, Peymon; Yang, Kai; Burkett, Geroge; Boone, John M.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8668 2013. 86681D.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gazi, P, Yang, K, Burkett, G & Boone, JM 2013, Development and spatial resolution characterization of a dedicated pulsed X-ray, cone-beam breast CT system. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8668, 86681D, Medical Imaging 2013: Physics of Medical Imaging, Lake Buena Vista, FL, United States, 2/11/13. https://doi.org/10.1117/12.2007648
Gazi P, Yang K, Burkett G, Boone JM. Development and spatial resolution characterization of a dedicated pulsed X-ray, cone-beam breast CT system. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8668. 2013. 86681D https://doi.org/10.1117/12.2007648
Gazi, Peymon ; Yang, Kai ; Burkett, Geroge ; Boone, John M. / Development and spatial resolution characterization of a dedicated pulsed X-ray, cone-beam breast CT system. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8668 2013.
@inproceedings{b3af032787354c30a178160f004a6b85,
title = "Development and spatial resolution characterization of a dedicated pulsed X-ray, cone-beam breast CT system",
abstract = "Dedicated breast CT (bCT) technology may be useful for patients with high risk of developing breast cancer. Previous studies have shown that bCT outperforms mammography in the visualization of mass lesions, however mammography is superior in identifying microcalcifications. The Breast Tomography Project at UC Davis has led to development of three dedicated breast CT scanners that produce high resolution, fully tomographic images, overcoming tissue superposition effects found in mammography while maintaining an equivalent radiation dose. Over 600 patients have been imaged in an ongoing clinical trial. The first patient scan was performed on the latest bCT scanner developed at UC Davis, called Cambria, on April 12, 2012. The main differences between Cambria and the previous scanners are in using a pulsed xray source (generator and tube) instead of continuous x-ray sources, and also in using the non-binning mode of the flatpanel fluoroscopic detector. The spatial resolution characteristics of the new scanner were investigated and the results show significant improvement in the overall MTF properties. Based on these results, it was concluded that using the pulsed x-ray tube, we were able to restore the MTF degradation caused by motion blurring effect that exists in previous generations of bCT. Moreover, MTF analysis shows that using the detector in the native acquisition mode (1 x 1) results in superior spatial resolution which will likely bring considerable improvement to the delineation of microcalcifications.",
keywords = "Cone-beam CT, MTF",
author = "Peymon Gazi and Kai Yang and Geroge Burkett and Boone, {John M}",
year = "2013",
doi = "10.1117/12.2007648",
language = "English (US)",
isbn = "9780819494429",
volume = "8668",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - Development and spatial resolution characterization of a dedicated pulsed X-ray, cone-beam breast CT system

AU - Gazi, Peymon

AU - Yang, Kai

AU - Burkett, Geroge

AU - Boone, John M

PY - 2013

Y1 - 2013

N2 - Dedicated breast CT (bCT) technology may be useful for patients with high risk of developing breast cancer. Previous studies have shown that bCT outperforms mammography in the visualization of mass lesions, however mammography is superior in identifying microcalcifications. The Breast Tomography Project at UC Davis has led to development of three dedicated breast CT scanners that produce high resolution, fully tomographic images, overcoming tissue superposition effects found in mammography while maintaining an equivalent radiation dose. Over 600 patients have been imaged in an ongoing clinical trial. The first patient scan was performed on the latest bCT scanner developed at UC Davis, called Cambria, on April 12, 2012. The main differences between Cambria and the previous scanners are in using a pulsed xray source (generator and tube) instead of continuous x-ray sources, and also in using the non-binning mode of the flatpanel fluoroscopic detector. The spatial resolution characteristics of the new scanner were investigated and the results show significant improvement in the overall MTF properties. Based on these results, it was concluded that using the pulsed x-ray tube, we were able to restore the MTF degradation caused by motion blurring effect that exists in previous generations of bCT. Moreover, MTF analysis shows that using the detector in the native acquisition mode (1 x 1) results in superior spatial resolution which will likely bring considerable improvement to the delineation of microcalcifications.

AB - Dedicated breast CT (bCT) technology may be useful for patients with high risk of developing breast cancer. Previous studies have shown that bCT outperforms mammography in the visualization of mass lesions, however mammography is superior in identifying microcalcifications. The Breast Tomography Project at UC Davis has led to development of three dedicated breast CT scanners that produce high resolution, fully tomographic images, overcoming tissue superposition effects found in mammography while maintaining an equivalent radiation dose. Over 600 patients have been imaged in an ongoing clinical trial. The first patient scan was performed on the latest bCT scanner developed at UC Davis, called Cambria, on April 12, 2012. The main differences between Cambria and the previous scanners are in using a pulsed xray source (generator and tube) instead of continuous x-ray sources, and also in using the non-binning mode of the flatpanel fluoroscopic detector. The spatial resolution characteristics of the new scanner were investigated and the results show significant improvement in the overall MTF properties. Based on these results, it was concluded that using the pulsed x-ray tube, we were able to restore the MTF degradation caused by motion blurring effect that exists in previous generations of bCT. Moreover, MTF analysis shows that using the detector in the native acquisition mode (1 x 1) results in superior spatial resolution which will likely bring considerable improvement to the delineation of microcalcifications.

KW - Cone-beam CT

KW - MTF

UR - http://www.scopus.com/inward/record.url?scp=84878335287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878335287&partnerID=8YFLogxK

U2 - 10.1117/12.2007648

DO - 10.1117/12.2007648

M3 - Conference contribution

AN - SCOPUS:84878335287

SN - 9780819494429

VL - 8668

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -