TY - JOUR
T1 - Development and regeneration of hair cells share common functional features
AU - Levic, Snezana
AU - Nie, Liping
AU - Tuteja, Dipika
AU - Harvey, Margaret
AU - Sokolowski, Bernd H A
AU - Yamoah, Ebenezer N.
PY - 2007/11/27
Y1 - 2007/11/27
N2 - The structural phenotype of neural connections in the auditory brainstem is sculpted by spontaneous and stimulus-induced neural activities during development. However, functional and molecular mechanisms of spontaneous action potentials (SAPs) in the developing cochlea are unknown. Additionally, it is unclear how regenerating hair cells establish their neural ranking in the constellation of neurons in the brainstem. We have demonstrated that a transient Ca2+ current produced by the Cav3.1 channel is expressed early in development to initiate spontaneous Ca2+ spikes. Ca v1.3 currents, typical of mature hair cells, appeared later in development. Moreover, there is a surprising disappearance of the Ca v3.1 current that coincides with the attenuation of the transient Ca2+ current as the electrical properties of hair cells transition to the mature phenotype. Remarkably, this process is recapitulated during hair-cell regeneration, suggesting that the transient expression of Ca v3.1 and the ensuing SAPs are signatures of hair cell development and regeneration.
AB - The structural phenotype of neural connections in the auditory brainstem is sculpted by spontaneous and stimulus-induced neural activities during development. However, functional and molecular mechanisms of spontaneous action potentials (SAPs) in the developing cochlea are unknown. Additionally, it is unclear how regenerating hair cells establish their neural ranking in the constellation of neurons in the brainstem. We have demonstrated that a transient Ca2+ current produced by the Cav3.1 channel is expressed early in development to initiate spontaneous Ca2+ spikes. Ca v1.3 currents, typical of mature hair cells, appeared later in development. Moreover, there is a surprising disappearance of the Ca v3.1 current that coincides with the attenuation of the transient Ca2+ current as the electrical properties of hair cells transition to the mature phenotype. Remarkably, this process is recapitulated during hair-cell regeneration, suggesting that the transient expression of Ca v3.1 and the ensuing SAPs are signatures of hair cell development and regeneration.
KW - Ca currents
KW - Cochlea
KW - Hearing
KW - Spontaneous activity
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U2 - 10.1073/pnas.0705927104
DO - 10.1073/pnas.0705927104
M3 - Article
C2 - 18025474
AN - SCOPUS:37649020914
VL - 104
SP - 19108
EP - 19113
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 48
ER -