Development and Characterization of the BALB/cNIV Mouse Strain

Lawrence J.T. Young, Robert Cardiff, Kenneth B. DeOme, Dorothy R. Pitelka, Phyllis B. Blair

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The strain BALB/cNIV/Crgl was developed by infecting BALB/ c/Crgl mice with mouse mammary tumor virus from C3Hf mice. A BALB/c normal mammary duct was transplanted into the gland-free fat pad of a hormone-stimulated female C3Hf x BALB/ c Fi mouse. A hyperplastic alveolar nodule was found in the BALB/c ductal outgrowth and was transplanted into another hybrid gland-free fat pad. The resultant hyperplastic alveolar outgrowth was finally transplanted to female BALB/c mice. The hyperplastic alveolar outgrowth contained an exogenous, infectious mouse mammary tumor virus named the nodule-inducing virus, which was thought to be derived from the endogenous low oncogenic mouse mammary tumor virus found in C3Hf mice. The hyperplastic alveolar outgrowth-bearing BALB/c mice were inbred for four generations, and one family was selected as the strain BALB/cNIV/Crgl. It was found that (a) the mouse mammary tumor virus found in the BALB/cNIV strain was milk transmitted, but not transmitted by infected males; (b) the BALB/cNIV breeding females had a low tumor incidence (40%) and a longer latent period (14 months) than did female BALB/cfC3H mice (92% at 8 months); (c) the BALB/cNIV nodule outgrowths had low tumor-producing capabilities (50%) and longer latent periods (13.4 months) than did nodule outgrowths derived from female BALB/cfC3H mice (100% at 7.7 months).

Original languageEnglish (US)
Pages (from-to)4333-4336
Number of pages4
JournalCancer Research
Volume44
Issue number10
StatePublished - Oct 1 1984

Fingerprint

Mouse mammary tumor virus
Adipose Tissue
Breeding
Neoplasms
Milk
Breast
Hormones
Viruses
Incidence

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Young, L. J. T., Cardiff, R., DeOme, K. B., Pitelka, D. R., & Blair, P. B. (1984). Development and Characterization of the BALB/cNIV Mouse Strain. Cancer Research, 44(10), 4333-4336.

Development and Characterization of the BALB/cNIV Mouse Strain. / Young, Lawrence J.T.; Cardiff, Robert; DeOme, Kenneth B.; Pitelka, Dorothy R.; Blair, Phyllis B.

In: Cancer Research, Vol. 44, No. 10, 01.10.1984, p. 4333-4336.

Research output: Contribution to journalArticle

Young, LJT, Cardiff, R, DeOme, KB, Pitelka, DR & Blair, PB 1984, 'Development and Characterization of the BALB/cNIV Mouse Strain', Cancer Research, vol. 44, no. 10, pp. 4333-4336.
Young LJT, Cardiff R, DeOme KB, Pitelka DR, Blair PB. Development and Characterization of the BALB/cNIV Mouse Strain. Cancer Research. 1984 Oct 1;44(10):4333-4336.
Young, Lawrence J.T. ; Cardiff, Robert ; DeOme, Kenneth B. ; Pitelka, Dorothy R. ; Blair, Phyllis B. / Development and Characterization of the BALB/cNIV Mouse Strain. In: Cancer Research. 1984 ; Vol. 44, No. 10. pp. 4333-4336.
@article{354f8328c5364554bbebf904f79fde78,
title = "Development and Characterization of the BALB/cNIV Mouse Strain",
abstract = "The strain BALB/cNIV/Crgl was developed by infecting BALB/ c/Crgl mice with mouse mammary tumor virus from C3Hf mice. A BALB/c normal mammary duct was transplanted into the gland-free fat pad of a hormone-stimulated female C3Hf x BALB/ c Fi mouse. A hyperplastic alveolar nodule was found in the BALB/c ductal outgrowth and was transplanted into another hybrid gland-free fat pad. The resultant hyperplastic alveolar outgrowth was finally transplanted to female BALB/c mice. The hyperplastic alveolar outgrowth contained an exogenous, infectious mouse mammary tumor virus named the nodule-inducing virus, which was thought to be derived from the endogenous low oncogenic mouse mammary tumor virus found in C3Hf mice. The hyperplastic alveolar outgrowth-bearing BALB/c mice were inbred for four generations, and one family was selected as the strain BALB/cNIV/Crgl. It was found that (a) the mouse mammary tumor virus found in the BALB/cNIV strain was milk transmitted, but not transmitted by infected males; (b) the BALB/cNIV breeding females had a low tumor incidence (40{\%}) and a longer latent period (14 months) than did female BALB/cfC3H mice (92{\%} at 8 months); (c) the BALB/cNIV nodule outgrowths had low tumor-producing capabilities (50{\%}) and longer latent periods (13.4 months) than did nodule outgrowths derived from female BALB/cfC3H mice (100{\%} at 7.7 months).",
author = "Young, {Lawrence J.T.} and Robert Cardiff and DeOme, {Kenneth B.} and Pitelka, {Dorothy R.} and Blair, {Phyllis B.}",
year = "1984",
month = "10",
day = "1",
language = "English (US)",
volume = "44",
pages = "4333--4336",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "10",

}

TY - JOUR

T1 - Development and Characterization of the BALB/cNIV Mouse Strain

AU - Young, Lawrence J.T.

AU - Cardiff, Robert

AU - DeOme, Kenneth B.

AU - Pitelka, Dorothy R.

AU - Blair, Phyllis B.

PY - 1984/10/1

Y1 - 1984/10/1

N2 - The strain BALB/cNIV/Crgl was developed by infecting BALB/ c/Crgl mice with mouse mammary tumor virus from C3Hf mice. A BALB/c normal mammary duct was transplanted into the gland-free fat pad of a hormone-stimulated female C3Hf x BALB/ c Fi mouse. A hyperplastic alveolar nodule was found in the BALB/c ductal outgrowth and was transplanted into another hybrid gland-free fat pad. The resultant hyperplastic alveolar outgrowth was finally transplanted to female BALB/c mice. The hyperplastic alveolar outgrowth contained an exogenous, infectious mouse mammary tumor virus named the nodule-inducing virus, which was thought to be derived from the endogenous low oncogenic mouse mammary tumor virus found in C3Hf mice. The hyperplastic alveolar outgrowth-bearing BALB/c mice were inbred for four generations, and one family was selected as the strain BALB/cNIV/Crgl. It was found that (a) the mouse mammary tumor virus found in the BALB/cNIV strain was milk transmitted, but not transmitted by infected males; (b) the BALB/cNIV breeding females had a low tumor incidence (40%) and a longer latent period (14 months) than did female BALB/cfC3H mice (92% at 8 months); (c) the BALB/cNIV nodule outgrowths had low tumor-producing capabilities (50%) and longer latent periods (13.4 months) than did nodule outgrowths derived from female BALB/cfC3H mice (100% at 7.7 months).

AB - The strain BALB/cNIV/Crgl was developed by infecting BALB/ c/Crgl mice with mouse mammary tumor virus from C3Hf mice. A BALB/c normal mammary duct was transplanted into the gland-free fat pad of a hormone-stimulated female C3Hf x BALB/ c Fi mouse. A hyperplastic alveolar nodule was found in the BALB/c ductal outgrowth and was transplanted into another hybrid gland-free fat pad. The resultant hyperplastic alveolar outgrowth was finally transplanted to female BALB/c mice. The hyperplastic alveolar outgrowth contained an exogenous, infectious mouse mammary tumor virus named the nodule-inducing virus, which was thought to be derived from the endogenous low oncogenic mouse mammary tumor virus found in C3Hf mice. The hyperplastic alveolar outgrowth-bearing BALB/c mice were inbred for four generations, and one family was selected as the strain BALB/cNIV/Crgl. It was found that (a) the mouse mammary tumor virus found in the BALB/cNIV strain was milk transmitted, but not transmitted by infected males; (b) the BALB/cNIV breeding females had a low tumor incidence (40%) and a longer latent period (14 months) than did female BALB/cfC3H mice (92% at 8 months); (c) the BALB/cNIV nodule outgrowths had low tumor-producing capabilities (50%) and longer latent periods (13.4 months) than did nodule outgrowths derived from female BALB/cfC3H mice (100% at 7.7 months).

UR - http://www.scopus.com/inward/record.url?scp=0021231316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021231316&partnerID=8YFLogxK

M3 - Article

C2 - 6088036

AN - SCOPUS:0021231316

VL - 44

SP - 4333

EP - 4336

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 10

ER -