Development and characterization of 5 canine B-cell lymphoma cell lines

Allison Zwingenberger, William Vernau, Changying Shi, Wensheng Yan, Xinbin Chen, Ira K. Gordon, Michael S Kent

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Canine and human lymphoma share similar characteristics in disease development and response to therapy. Translational research can be furthered using tools such as canine cell lines to model therapeutic compounds and strategies. We developed 5 B-cell lymphoma cell lines from dogs with confirmed large B-cell lymphoma. These cell lines were CD3, CD18, CD20, and CD90 positive with variable CD79a, CD1c and CD34 expression. All cell lines were tumorigenic in Nu/nu mice and were wild type for p53. Canine lymphoma cell lines serve as an important resource for translational lymphoma research.

Original languageEnglish (US)
Pages (from-to)601-606
Number of pages6
JournalLeukemia Research
Volume36
Issue number5
DOIs
StatePublished - May 2012

Keywords

  • B-cell lymphoma
  • Canine
  • Cell line
  • Non-Hodgkin's

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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