Developing stem cell therapies for juvenile and adult-onset Huntington's disease

Kyle D. Fink, Peter Deng, Audrey Torrest, Heather Stewart, Kari Pollock, William Gruenloh, Geralyn Annett, Teresa Tempkin, Vicki Wheelock, Jan A. Nolta

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Stem cell therapies have been explored as a new avenue for the treatment of neurologic disease and damage within the CNS in part due to their native ability to mimic repair mechanisms in the brain. Mesenchymal stem cells have been of particular clinical interest due to their ability to release beneficial neurotrophic factors and their ability to foster a neuroprotective microenviroment. While early stem cell transplantation therapies have been fraught with technical and political concerns as well as limited clinical benefits, mesenchymal stem cell therapies have been shown to be clinically beneficial and derivable from nonembryonic, adult sources. The focus of this review will be on emerging and extant stem cell therapies for juvenile and adult-onset Huntington's disease.

Original languageEnglish (US)
Pages (from-to)623-646
Number of pages24
JournalRegenerative Medicine
Volume10
Issue number5
DOIs
StatePublished - Aug 1 2015

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Keywords

  • Huntington's disease
  • regenerative medicine
  • stem cell
  • transplantation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology

Cite this

Fink, K. D., Deng, P., Torrest, A., Stewart, H., Pollock, K., Gruenloh, W., Annett, G., Tempkin, T., Wheelock, V., & Nolta, J. A. (2015). Developing stem cell therapies for juvenile and adult-onset Huntington's disease. Regenerative Medicine, 10(5), 623-646. https://doi.org/10.2217/rme.15.25