Determining the pharmacokinetics and long-term biodistribution of SiO 2 nanoparticles in Vivo using accelerator mass spectrometry

Michael A. Malfatti, Heather A. Palko, Edward A. Kuhn, Ken W Turteltaub

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Biodistribution is an important factor in better understanding silica dioxide nanoparticle (SiNP) safety. Currently, comprehensive studies on biodistribution are lacking, most likely due to the lack of suitable analytical methods. Accelerator mass spectrometry was used to investigate the relationship between administered dose, pharmacokinetics (PK), and long-term biodistribution of 14C-SiNPs in vivo. PK analysis showed that SiNPs were rapidly cleared from the central compartment, were distributed to tissues of the reticuloendothelial system, and persisted in the tissue over the 8 week time course, raising questions about the potential for bioaccumulation and associated long-term effects.

Original languageEnglish (US)
Pages (from-to)5532-5538
Number of pages7
JournalNano Letters
Volume12
Issue number11
DOIs
StatePublished - Nov 14 2012
Externally publishedYes

Fingerprint

Pharmacokinetics
Particle accelerators
Mass spectrometry
accelerators
mass spectroscopy
Tissue
Nanoparticles
long term effects
nanoparticles
Bioaccumulation
compartments
dioxides
Silicon Dioxide
safety
Silica
silicon dioxide
dosage

Keywords

  • Accelerator mass spectrometry
  • bioaccumulation
  • biodistribution
  • pharmacokinetics
  • silica nanoparticles

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

Cite this

Determining the pharmacokinetics and long-term biodistribution of SiO 2 nanoparticles in Vivo using accelerator mass spectrometry. / Malfatti, Michael A.; Palko, Heather A.; Kuhn, Edward A.; Turteltaub, Ken W.

In: Nano Letters, Vol. 12, No. 11, 14.11.2012, p. 5532-5538.

Research output: Contribution to journalArticle

Malfatti, Michael A. ; Palko, Heather A. ; Kuhn, Edward A. ; Turteltaub, Ken W. / Determining the pharmacokinetics and long-term biodistribution of SiO 2 nanoparticles in Vivo using accelerator mass spectrometry. In: Nano Letters. 2012 ; Vol. 12, No. 11. pp. 5532-5538.
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