Determination of vitamin A and its metabolites in rat testis: Possible involvement of vitamin a in testicular toxicity caused by molinate

Fabiola G. Zuno-Floriano, Dirk Holstege, Matt J. Hengel, Nilesh W. Gaikwad, Maria L. Aldana-Madrid, Marion G. Miller

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

This study was conducted to evaluate the effect of molinate on retinoids homeostasis in rat testis. Molinate was administrated to male Sprague-Dawley rats (200 mg kg -1 in corn oil, ip). Retinoid measurements were made at 6, 12, 48 and 168 h time points after administration. Testis levels of retinoic acid decreased (32 %) in a statistically significant manner at the 12 and 48 h time points. However, retinol and retinaldehyde were not significantly affected by molinate. These results suggest that molinate affects retinoic acid synthesis in testis and could contribute to understanding the molecular mechanism of molinate involved testicular toxicity.

Original languageEnglish (US)
Pages (from-to)1038-1042
Number of pages5
JournalBulletin of Environmental Contamination and Toxicology
Volume88
Issue number6
DOIs
StatePublished - Jun 2012

Keywords

  • Molinate
  • Retinoic acid
  • Retinoids
  • Testicular-toxicity

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Pollution
  • Toxicology

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