Determination of the minimum anesthetic concentration of sevoflurane in thick-billed parrots (Rhynchopsitta pachyrhyncha)

Kristen A. Phair, R. Scott Larsen, Raymund F. Wack, Yael Shilo-Benjamini, Bruno H Pypendop

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective-To determine the minimum anesthetic concentration (MAC) of sevoflurane in thick-billed parrots (Rhynchopsitta pachyrhyncha) and compare MAC obtained via mechanical and electrical stimulation. Animals-15 healthy thick-billed parrots. Procedures-Anesthesia was induced in each parrot by administration of sevoflurane in oxygen. An end-tidal sevoflurane concentration of 2.5% was established in the first bird. Fifteen minutes was allowed for equilibration. Then, 2 types of noxious stimulation (mechanical and electrical) were applied; stimuli were separated by 15 minutes. Responses to stimuli were graded as positive or negative. For a positive or negative response to a stimulus, the target end-tidal sevoflurane concentration of the subsequent bird was increased or decreased by 10%, respectively. The MAC was calculated as the mean end-tidal sevoflurane concentration during crossover events, defined as instances in which independent pairs of birds evaluated in succession had opposite responses. A quantal method was used todetermine sevoflurane MAC. Physiologic variables and arterial blood gas values were also measured. Results-Via quantal analysis, mean sevoflurane MAC in thick-billed parrots determined with mechanical stimulation was 2.35% (90% fiducial interval, 1.32% to 2.66%), which differed significantly from the mean sevoflurane MAC determined with electrical stimulation, which was 4.24% (90% fiducial interval, 3.61% to 8.71%). Conclusions and Clinical Relevance-Sevoflurane MAC in thick-billed parrots determined by mechanical stimulation was similar to values determined in chickens and mammals. Sevoflurane MAC determined by electrical stimulation was significantly higher, which suggested that the 2 types of stimulation did not induce similar results in thick-billed parrots.

Original languageEnglish (US)
Pages (from-to)1350-1355
Number of pages6
JournalAmerican Journal of Veterinary Research
Volume73
Issue number9
DOIs
StatePublished - Sep 2012

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Parrots
anesthetics
Anesthetics
Electric Stimulation
Birds
birds
sevoflurane
Rhynchopsitta pachyrhyncha
parrots
blood gases
anesthesia
mammals
chickens
Mammals
Chickens
oxygen
Anesthesia
Gases

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Determination of the minimum anesthetic concentration of sevoflurane in thick-billed parrots (Rhynchopsitta pachyrhyncha). / Phair, Kristen A.; Scott Larsen, R.; Wack, Raymund F.; Shilo-Benjamini, Yael; Pypendop, Bruno H.

In: American Journal of Veterinary Research, Vol. 73, No. 9, 09.2012, p. 1350-1355.

Research output: Contribution to journalArticle

Phair, Kristen A. ; Scott Larsen, R. ; Wack, Raymund F. ; Shilo-Benjamini, Yael ; Pypendop, Bruno H. / Determination of the minimum anesthetic concentration of sevoflurane in thick-billed parrots (Rhynchopsitta pachyrhyncha). In: American Journal of Veterinary Research. 2012 ; Vol. 73, No. 9. pp. 1350-1355.
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abstract = "Objective-To determine the minimum anesthetic concentration (MAC) of sevoflurane in thick-billed parrots (Rhynchopsitta pachyrhyncha) and compare MAC obtained via mechanical and electrical stimulation. Animals-15 healthy thick-billed parrots. Procedures-Anesthesia was induced in each parrot by administration of sevoflurane in oxygen. An end-tidal sevoflurane concentration of 2.5{\%} was established in the first bird. Fifteen minutes was allowed for equilibration. Then, 2 types of noxious stimulation (mechanical and electrical) were applied; stimuli were separated by 15 minutes. Responses to stimuli were graded as positive or negative. For a positive or negative response to a stimulus, the target end-tidal sevoflurane concentration of the subsequent bird was increased or decreased by 10{\%}, respectively. The MAC was calculated as the mean end-tidal sevoflurane concentration during crossover events, defined as instances in which independent pairs of birds evaluated in succession had opposite responses. A quantal method was used todetermine sevoflurane MAC. Physiologic variables and arterial blood gas values were also measured. Results-Via quantal analysis, mean sevoflurane MAC in thick-billed parrots determined with mechanical stimulation was 2.35{\%} (90{\%} fiducial interval, 1.32{\%} to 2.66{\%}), which differed significantly from the mean sevoflurane MAC determined with electrical stimulation, which was 4.24{\%} (90{\%} fiducial interval, 3.61{\%} to 8.71{\%}). Conclusions and Clinical Relevance-Sevoflurane MAC in thick-billed parrots determined by mechanical stimulation was similar to values determined in chickens and mammals. Sevoflurane MAC determined by electrical stimulation was significantly higher, which suggested that the 2 types of stimulation did not induce similar results in thick-billed parrots.",
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