Determination of prevalence of depression in an epilepsy clinic using a brief DSM-IV-based self-report questionnaire

Nicole A. Seminario, Sarah E Tomaszewski Farias, Julie Jorgensen, James A. Bourgeois, Masud Seyal

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Depression in epilepsy is common, underrecognized, and an indicator of quality of life. The Patient Health Questionnaire nine-item depression scale (PHQ-9) is a self-administered questionnaire based on Diagnostic and Statistical Manual, Fourth Edition (DSM-IV) criteria with high sensitivity and specificity for diagnosing depression. Using the PHQ-9, we determined that one-third of 263 patients seen in an epilepsy clinic had scores consistent with major depression. Seizure-free patients had lower depression scores than those with persistent seizures. Depression scores were not related to the number or type of antiepileptic drugs used. One-half of patients with scores consistent with major depression were not on antidepressant medication. The brevity of the PHQ-9 is conducive to routine screening of patients with epilepsy.

Original languageEnglish (US)
Pages (from-to)362-366
Number of pages5
JournalEpilepsy and Behavior
Volume15
Issue number3
DOIs
StatePublished - Jul 2009

Keywords

  • Depression
  • Diagnostic and Statistical Manual, Fourth Edition
  • Epilepsy
  • Patient Health Questionnaire nine-item depression scale (PHQ-9)
  • Screening

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

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