Determination of nanoparticle size distribution together with density or molecular weight by 2D analytical ultracentrifugation

Randy Carney, Jin Young Kim, Huifeng Qian, Rongchao Jin, Hakim Mehenni, Francesco Stellacci, Osman M. Bakr

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

Nanoparticles are finding many research and industrial applications, yet their characterization remains a challenge. Their cores are often polydisperse and coated by a stabilizing shell that varies in size and composition. No single technique can characterize both the size distribution and the nature of the shell. Advances in analytical ultracentrifugation allow for the extraction of the sedimentation (s) and diffusion coefficients (D). Here we report an approach to transform the s and D distributions of nanoparticles in solution into precise molecular weight (M), density (ρP) and particle diameter (dp) distributions. M for mixtures of discrete nanocrystals is found within 4% of the known quantities. The accuracy and the density information we achieve on nanoparticles are unparalleled. A single experimental run is sufficient for full nanoparticle characterization, without the need for standards or other auxiliary measurements. We believe that our method is of general applicability and we discuss its limitations.

Original languageEnglish (US)
Article number335
JournalNature Communications
Volume2
Issue number1
DOIs
StatePublished - Jun 15 2011
Externally publishedYes

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Ultracentrifugation
Nanoparticles
molecular weight
Molecular Weight
Molecular weight
nanoparticles
Sedimentation
Nanocrystals
Industrial applications
nanocrystals
diffusion coefficient
Chemical analysis
Research

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Determination of nanoparticle size distribution together with density or molecular weight by 2D analytical ultracentrifugation. / Carney, Randy; Kim, Jin Young; Qian, Huifeng; Jin, Rongchao; Mehenni, Hakim; Stellacci, Francesco; Bakr, Osman M.

In: Nature Communications, Vol. 2, No. 1, 335, 15.06.2011.

Research output: Contribution to journalArticle

Carney, Randy ; Kim, Jin Young ; Qian, Huifeng ; Jin, Rongchao ; Mehenni, Hakim ; Stellacci, Francesco ; Bakr, Osman M. / Determination of nanoparticle size distribution together with density or molecular weight by 2D analytical ultracentrifugation. In: Nature Communications. 2011 ; Vol. 2, No. 1.
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