Determination of bone volume by osteocyte population

D. Vashishth, G. Gibson, J. Kimura, M. B. Schaffler, David P Fyhrie

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

During development and growth, biological tissues and organisms can control their size and mass by regulating cell number (Raff, 1992; Conlon and Raff, 1999). Later in life both cell number and organ mass decrease (Buetow, 1985). We demonstrate that the number density of bone cells buried in the calcified matrix (osteocyte lacunar density) predicts extracellular matrix volume for both cancellous and cortical bone in a broad cross-section of the population (males and females, age range 23-91 years, r2 = 0.98). Our hypothesis is that bone mass is determined by the control of osteocyte number, and that this is a particular instance of the control of organ size through the social controls on cell survival and death (Raff, 1992; Conlon and Raff, 1999).

Original languageEnglish (US)
Pages (from-to)292-295
Number of pages4
JournalAnatomical Record
Volume267
Issue number4
DOIs
StatePublished - Aug 1 2002
Externally publishedYes

Fingerprint

Osteocytes
bone
Cell Count
bones
Bone and Bones
Population
matrix
Organ Size
bone density
cells
Growth and Development
extracellular matrix
growth and development
Bone Density
cell viability
Extracellular Matrix
cell death
Cell Survival
Cell Death
cross section

Keywords

  • Bone
  • Osteocyte
  • Osteoporosis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anatomy

Cite this

Vashishth, D., Gibson, G., Kimura, J., Schaffler, M. B., & Fyhrie, D. P. (2002). Determination of bone volume by osteocyte population. Anatomical Record, 267(4), 292-295. https://doi.org/10.1002/ar.10114

Determination of bone volume by osteocyte population. / Vashishth, D.; Gibson, G.; Kimura, J.; Schaffler, M. B.; Fyhrie, David P.

In: Anatomical Record, Vol. 267, No. 4, 01.08.2002, p. 292-295.

Research output: Contribution to journalArticle

Vashishth, D, Gibson, G, Kimura, J, Schaffler, MB & Fyhrie, DP 2002, 'Determination of bone volume by osteocyte population', Anatomical Record, vol. 267, no. 4, pp. 292-295. https://doi.org/10.1002/ar.10114
Vashishth D, Gibson G, Kimura J, Schaffler MB, Fyhrie DP. Determination of bone volume by osteocyte population. Anatomical Record. 2002 Aug 1;267(4):292-295. https://doi.org/10.1002/ar.10114
Vashishth, D. ; Gibson, G. ; Kimura, J. ; Schaffler, M. B. ; Fyhrie, David P. / Determination of bone volume by osteocyte population. In: Anatomical Record. 2002 ; Vol. 267, No. 4. pp. 292-295.
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