Determinants of prolactin in postmenopausal Chinese women in Singapore

Tiffany A. Katz, Anna H. Wu, Frank Z. Stanczyk, Renwei Wang, Woon Puay Koh, Jian Min Yuan, Steffi Oesterreich, Lesley M. Butler

Research output: Contribution to journalArticle

Abstract

Purpose: Mechanistic and observational data together support a role for prolactin in breast cancer development. Determinants of prolactin in Asian populations have not been meaningfully explored, despite the lower risk of breast cancer in Asian populations. Methods: Determinants of plasma prolactin were evaluated in 442 postmenopausal women enrolled in the Singapore Chinese Health Study, a population-based prospective cohort study. At baseline all cohort members completed an in-person interview that elicited information on diet, menstrual and reproductive history, and lifestyle factors. One year after cohort initiation we began collecting blood samples. Quantified were plasma concentrations of prolactin, estrone, estradiol, testosterone, androstenedione, and sex hormone-binding globulin (SHBG). Analysis of covariance method was used for statistical analyses with age at blood draw, time since last meal, and time at blood draw as covariates. Results: Mean prolactin levels were 25.1% lower with older age at menarche (p value = 0.001), and 27.6% higher with greater years between menarche and menopause (p value = 0.009). Prolactin levels were also positively associated with increased sleep duration (p value = 0.005). The independent determinants of prolactin were years from menarche to menopause, hours of sleep, and the plasma hormones estrone and SHBG (all p values < 0.01). Conclusion: The role of prolactin in breast cancer development may involve reproductive and lifestyle factors, such as a longer duration of menstrual cycling and sleep patterns.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalCancer Causes and Control
DOIs
StateAccepted/In press - Nov 9 2017
Externally publishedYes

Fingerprint

Singapore
Prolactin
Menarche
Sex Hormone-Binding Globulin
Sleep
Estrone
Breast Neoplasms
Menopause
Life Style
Population
Reproductive History
Androstenedione
Meals
Testosterone
Estradiol
Cohort Studies
Hormones
Prospective Studies
Interviews
Diet

Keywords

  • Breast cancer
  • Chinese
  • Hormones
  • Menstrual factors
  • Prolactin
  • Sleep

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Katz, T. A., Wu, A. H., Stanczyk, F. Z., Wang, R., Koh, W. P., Yuan, J. M., ... Butler, L. M. (Accepted/In press). Determinants of prolactin in postmenopausal Chinese women in Singapore. Cancer Causes and Control, 1-12. https://doi.org/10.1007/s10552-017-0978-8

Determinants of prolactin in postmenopausal Chinese women in Singapore. / Katz, Tiffany A.; Wu, Anna H.; Stanczyk, Frank Z.; Wang, Renwei; Koh, Woon Puay; Yuan, Jian Min; Oesterreich, Steffi; Butler, Lesley M.

In: Cancer Causes and Control, 09.11.2017, p. 1-12.

Research output: Contribution to journalArticle

Katz, TA, Wu, AH, Stanczyk, FZ, Wang, R, Koh, WP, Yuan, JM, Oesterreich, S & Butler, LM 2017, 'Determinants of prolactin in postmenopausal Chinese women in Singapore', Cancer Causes and Control, pp. 1-12. https://doi.org/10.1007/s10552-017-0978-8
Katz, Tiffany A. ; Wu, Anna H. ; Stanczyk, Frank Z. ; Wang, Renwei ; Koh, Woon Puay ; Yuan, Jian Min ; Oesterreich, Steffi ; Butler, Lesley M. / Determinants of prolactin in postmenopausal Chinese women in Singapore. In: Cancer Causes and Control. 2017 ; pp. 1-12.
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