Determinants of ovine compact bone viscoelastic properties: Effects of architecture, mineralization, and remodeling

C. M. Les, C. A. Spence, J. L. Vance, G. T. Christopherson, B. Patel, A. S. Turner, G. W. Divine, David P Fyhrie

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Significant decreases in ovine compact bone viscoelastic properties (specifically, stress-rate sensitivity, and damping efficiency) are associated with three years of ovariectomy and are particularly evident at higher frequencies [Proc. Orthop. Res. Soc. 27 (2002) 89]. It is unclear what materials or architectural features of bone are responsible for either the viscoelastic properties themselves, or for the changes in those properties that were observed with estrogen depletion. In this study, we examined the relationship between these viscoelastic mechanical properties and features involving bone architecture (BV/TV), materials parameters (ash density, %mineralization), and histologic evidence of remodeling (%remodeled, cement line interface). The extent of mineralization was inversely proportional to the material's efficiency in damping stress oscillations. The damping characteristics of bone material from ovariectomized animals were significantly more sensitive to variation in mineralization than was bone from control animals. At low frequencies (6 Hz or less), increased histologic evidence of remodeling was positively correlated with increased damping efficiency. However, the dramatic decreases in stress-rate sensitivity that accompanied 3-year ovariectomy were seen throughout the bone structure and occurred even in areas with little or no secondary Haversian remodeling as well as in areas of complete remodeling. Taken together, these data suggest that, while the mineral component may modify the viscoelastic behavior of bone, the basic mechanism underlying bone viscoelastic behavior, and of the changes in that behavior with estrogen depletion, reside in a non-mineral component of the bone that can be significantly altered in the absence of secondary remodeling.

Original languageEnglish (US)
Pages (from-to)729-738
Number of pages10
JournalBone
Volume35
Issue number3
DOIs
StatePublished - Sep 2004
Externally publishedYes

Fingerprint

Sheep
Bone and Bones
Ovariectomy
Estrogens
Physiologic Calcification
Cortical Bone
Minerals

Keywords

  • Compact bone
  • Loss tangent
  • Mineralization
  • Remodeling
  • Storage modulus
  • Viscoelasticity

ASJC Scopus subject areas

  • Physiology
  • Hematology

Cite this

Determinants of ovine compact bone viscoelastic properties : Effects of architecture, mineralization, and remodeling. / Les, C. M.; Spence, C. A.; Vance, J. L.; Christopherson, G. T.; Patel, B.; Turner, A. S.; Divine, G. W.; Fyhrie, David P.

In: Bone, Vol. 35, No. 3, 09.2004, p. 729-738.

Research output: Contribution to journalArticle

Les, CM, Spence, CA, Vance, JL, Christopherson, GT, Patel, B, Turner, AS, Divine, GW & Fyhrie, DP 2004, 'Determinants of ovine compact bone viscoelastic properties: Effects of architecture, mineralization, and remodeling', Bone, vol. 35, no. 3, pp. 729-738. https://doi.org/10.1016/j.bone.2004.04.006
Les, C. M. ; Spence, C. A. ; Vance, J. L. ; Christopherson, G. T. ; Patel, B. ; Turner, A. S. ; Divine, G. W. ; Fyhrie, David P. / Determinants of ovine compact bone viscoelastic properties : Effects of architecture, mineralization, and remodeling. In: Bone. 2004 ; Vol. 35, No. 3. pp. 729-738.
@article{c17b03a77d76409d85315e300b81cece,
title = "Determinants of ovine compact bone viscoelastic properties: Effects of architecture, mineralization, and remodeling",
abstract = "Significant decreases in ovine compact bone viscoelastic properties (specifically, stress-rate sensitivity, and damping efficiency) are associated with three years of ovariectomy and are particularly evident at higher frequencies [Proc. Orthop. Res. Soc. 27 (2002) 89]. It is unclear what materials or architectural features of bone are responsible for either the viscoelastic properties themselves, or for the changes in those properties that were observed with estrogen depletion. In this study, we examined the relationship between these viscoelastic mechanical properties and features involving bone architecture (BV/TV), materials parameters (ash density, {\%}mineralization), and histologic evidence of remodeling ({\%}remodeled, cement line interface). The extent of mineralization was inversely proportional to the material's efficiency in damping stress oscillations. The damping characteristics of bone material from ovariectomized animals were significantly more sensitive to variation in mineralization than was bone from control animals. At low frequencies (6 Hz or less), increased histologic evidence of remodeling was positively correlated with increased damping efficiency. However, the dramatic decreases in stress-rate sensitivity that accompanied 3-year ovariectomy were seen throughout the bone structure and occurred even in areas with little or no secondary Haversian remodeling as well as in areas of complete remodeling. Taken together, these data suggest that, while the mineral component may modify the viscoelastic behavior of bone, the basic mechanism underlying bone viscoelastic behavior, and of the changes in that behavior with estrogen depletion, reside in a non-mineral component of the bone that can be significantly altered in the absence of secondary remodeling.",
keywords = "Compact bone, Loss tangent, Mineralization, Remodeling, Storage modulus, Viscoelasticity",
author = "Les, {C. M.} and Spence, {C. A.} and Vance, {J. L.} and Christopherson, {G. T.} and B. Patel and Turner, {A. S.} and Divine, {G. W.} and Fyhrie, {David P}",
year = "2004",
month = "9",
doi = "10.1016/j.bone.2004.04.006",
language = "English (US)",
volume = "35",
pages = "729--738",
journal = "Bone",
issn = "8756-3282",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Determinants of ovine compact bone viscoelastic properties

T2 - Effects of architecture, mineralization, and remodeling

AU - Les, C. M.

AU - Spence, C. A.

AU - Vance, J. L.

AU - Christopherson, G. T.

AU - Patel, B.

AU - Turner, A. S.

AU - Divine, G. W.

AU - Fyhrie, David P

PY - 2004/9

Y1 - 2004/9

N2 - Significant decreases in ovine compact bone viscoelastic properties (specifically, stress-rate sensitivity, and damping efficiency) are associated with three years of ovariectomy and are particularly evident at higher frequencies [Proc. Orthop. Res. Soc. 27 (2002) 89]. It is unclear what materials or architectural features of bone are responsible for either the viscoelastic properties themselves, or for the changes in those properties that were observed with estrogen depletion. In this study, we examined the relationship between these viscoelastic mechanical properties and features involving bone architecture (BV/TV), materials parameters (ash density, %mineralization), and histologic evidence of remodeling (%remodeled, cement line interface). The extent of mineralization was inversely proportional to the material's efficiency in damping stress oscillations. The damping characteristics of bone material from ovariectomized animals were significantly more sensitive to variation in mineralization than was bone from control animals. At low frequencies (6 Hz or less), increased histologic evidence of remodeling was positively correlated with increased damping efficiency. However, the dramatic decreases in stress-rate sensitivity that accompanied 3-year ovariectomy were seen throughout the bone structure and occurred even in areas with little or no secondary Haversian remodeling as well as in areas of complete remodeling. Taken together, these data suggest that, while the mineral component may modify the viscoelastic behavior of bone, the basic mechanism underlying bone viscoelastic behavior, and of the changes in that behavior with estrogen depletion, reside in a non-mineral component of the bone that can be significantly altered in the absence of secondary remodeling.

AB - Significant decreases in ovine compact bone viscoelastic properties (specifically, stress-rate sensitivity, and damping efficiency) are associated with three years of ovariectomy and are particularly evident at higher frequencies [Proc. Orthop. Res. Soc. 27 (2002) 89]. It is unclear what materials or architectural features of bone are responsible for either the viscoelastic properties themselves, or for the changes in those properties that were observed with estrogen depletion. In this study, we examined the relationship between these viscoelastic mechanical properties and features involving bone architecture (BV/TV), materials parameters (ash density, %mineralization), and histologic evidence of remodeling (%remodeled, cement line interface). The extent of mineralization was inversely proportional to the material's efficiency in damping stress oscillations. The damping characteristics of bone material from ovariectomized animals were significantly more sensitive to variation in mineralization than was bone from control animals. At low frequencies (6 Hz or less), increased histologic evidence of remodeling was positively correlated with increased damping efficiency. However, the dramatic decreases in stress-rate sensitivity that accompanied 3-year ovariectomy were seen throughout the bone structure and occurred even in areas with little or no secondary Haversian remodeling as well as in areas of complete remodeling. Taken together, these data suggest that, while the mineral component may modify the viscoelastic behavior of bone, the basic mechanism underlying bone viscoelastic behavior, and of the changes in that behavior with estrogen depletion, reside in a non-mineral component of the bone that can be significantly altered in the absence of secondary remodeling.

KW - Compact bone

KW - Loss tangent

KW - Mineralization

KW - Remodeling

KW - Storage modulus

KW - Viscoelasticity

UR - http://www.scopus.com/inward/record.url?scp=4344560874&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4344560874&partnerID=8YFLogxK

U2 - 10.1016/j.bone.2004.04.006

DO - 10.1016/j.bone.2004.04.006

M3 - Article

C2 - 15336610

AN - SCOPUS:4344560874

VL - 35

SP - 729

EP - 738

JO - Bone

JF - Bone

SN - 8756-3282

IS - 3

ER -