Determinants and functions of mitochondrial behavior

Katherine Labbé, Andrew Murley, Jodi Nunnari

Research output: Contribution to journalArticle

154 Scopus citations

Abstract

Mitochondria are ancient organelles evolved from bacteria. Over the course of evolution, the behavior of mitochondria inside eukaryotic cells has changed dramatically, and the corresponding machineries that control it are in most cases new inventions. The evolution of mitochondrial behavior reflects the necessity to create a dynamic compartment to integrate the myriad mitochondrial functions with the status of other endomembrane compartments, such as the endoplasmic reticulum, and with signaling pathways that monitor cellular homeostasis and respond to stress. Here we review what has been discovered about the molecular machineries that work together to control the collective behavior of mitochondria in cells, as well as their physiological roles in healthy and disease states.

Original languageEnglish (US)
Pages (from-to)357-391
Number of pages35
JournalAnnual Review of Cell and Developmental Biology
Volume30
Issue number1
DOIs
StatePublished - Oct 6 2014

Keywords

  • autophagy
  • mitochondrial dynamics
  • mitochondrial motility
  • mitochondrial tethering
  • mitophagy
  • mtDNA

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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