Deterioration of plasticity and metabolic homeostasis in the brain of the UCD-T2DM rat model of naturally occurring type-2 diabetes

Rahul Agrawal, Yumei Zhuang, Bethany P. Cummings, Kimber Stanhope, James L. Graham, Peter J Havel, Fernando Gomez-Pinilla

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The rising prevalence of type-2 diabetes is becoming a pressing issue based on emerging reports that T2DM can also adversely impact mental health. We have utilized the UCD-T2DM rat model in which the onset of T2DM develops spontaneously across time and can serve to understand the pathophysiology of diabetes in humans. An increased insulin resistance index and plasma glucose levels manifested the onset of T2DM. There was a decrease in hippocampal insulin receptor signaling in the hippocampus, which correlated with peripheral insulin resistance index along the course of diabetes onset (r = - 0.56, p < 0.01). T2DM increased the hippocampal levels of 4-hydroxynonenal (4-HNE; a marker of lipid peroxidation) in inverse proportion to the changes in the mitochondrial regulator PGC-1α. Disrupted energy homeostasis was further manifested by a concurrent reduction in energy metabolic markers, including TFAM, SIRT1, and AMPK phosphorylation. In addition, T2DM influenced brain plasticity as evidenced by a significant reduction of BDNF-TrkB signaling. These results suggest that the pathology of T2DM in the brain involves a progressive and coordinated disruption of insulin signaling, and energy homeostasis, with profound consequences for brain function and plasticity. All the described consequences of T2DM were attenuated by treatment with the glucagon-like peptide-1 receptor agonist, liraglutide. Similar results to those of liraglutide were obtained by exposing T2DM rats to a food energy restricted diet, which suggest that normalization of brain energy metabolism is a crucial factor to counteract central insulin sensitivity and synaptic plasticity associated with T2DM.

Original languageEnglish (US)
Pages (from-to)1313-1323
Number of pages11
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1842
Issue number9
DOIs
StatePublished - 2014

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Type 2 Diabetes Mellitus
Homeostasis
Insulin Resistance
Brain
AMP-Activated Protein Kinases
Neuronal Plasticity
Brain-Derived Neurotrophic Factor
Insulin Receptor
Vascular Resistance
Energy Metabolism
Lipid Peroxidation
Hippocampus
Mental Health
Phosphorylation
Insulin
Pathology
Diet
Glucose
Food
Liraglutide

Keywords

  • Dietary energy restriction
  • Energy homeostasis
  • Insulin signaling
  • Liraglutide
  • Plasticity
  • Type-2 diabetes

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

Cite this

Deterioration of plasticity and metabolic homeostasis in the brain of the UCD-T2DM rat model of naturally occurring type-2 diabetes. / Agrawal, Rahul; Zhuang, Yumei; Cummings, Bethany P.; Stanhope, Kimber; Graham, James L.; Havel, Peter J; Gomez-Pinilla, Fernando.

In: Biochimica et Biophysica Acta - Molecular Basis of Disease, Vol. 1842, No. 9, 2014, p. 1313-1323.

Research output: Contribution to journalArticle

Agrawal, Rahul ; Zhuang, Yumei ; Cummings, Bethany P. ; Stanhope, Kimber ; Graham, James L. ; Havel, Peter J ; Gomez-Pinilla, Fernando. / Deterioration of plasticity and metabolic homeostasis in the brain of the UCD-T2DM rat model of naturally occurring type-2 diabetes. In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 2014 ; Vol. 1842, No. 9. pp. 1313-1323.
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