Detection of simian immunodeficiency virus DNA in macrophages from infected rhesus macaques.

R. E. Unger, Marta Marthas, A. A. Lackner, E. Pratt-Lowe, B. L. Lohman, K. Van Rompay, Paul A Luciw

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

We have examined the frequency of infection of monocyte-derived and alveolar macrophages isolated from rhesus macaques inoculated with simian immunodeficiency virus (SIVmac) utilizing a semiquantitative PCR methodology. Animals were inoculated with either pathogenic (SIVmac239) or nonpathogenic (SIVmac1A11) molecularly cloned viruses of SIVmac, or with uncloned pathogenic SIVmacBIOL. The frequency of SIV DNA in macrophages was highest early after infection and at terminal stages of disease, whereas during the asymptomatic period, SIV DNA was present at very low levels in macrophages.

Original languageEnglish (US)
Pages (from-to)74-81
Number of pages8
JournalJournal of Medical Primatology
Volume21
Issue number2-3
StatePublished - Feb 1992

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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    Unger, R. E., Marthas, M., Lackner, A. A., Pratt-Lowe, E., Lohman, B. L., Van Rompay, K., & Luciw, P. A. (1992). Detection of simian immunodeficiency virus DNA in macrophages from infected rhesus macaques. Journal of Medical Primatology, 21(2-3), 74-81.