Abstract
Polymer-shelled contrast agents demonstrate unique properties because the enclosed gas oscillates freely only after the shell is damaged. We have observed this behavior optically using a high-speed camera, and hypothesize that it leads to the observed acoustical property that the response of a polymer-shelled bubble to a two-pulse sequence depends on the order of pulse transmission. We have observed this property in two different polymer-shelled contrast agents. Based on these findings, we designed a pulse sequence to detect polymer-shelled bubbles, "signal subtraction," in which two same-phase single-cycle pulses are transmitted in succession and the resulting echoes subtracted. This subtraction results in the cancellation of tissue echoes, even in the presence of tissue harmonic generation, with only a small reduction in bubble signal amplitude.
Original language | English (US) |
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Title of host publication | Proceedings of the IEEE Ultrasonics Symposium |
Editors | D.E. Yuhas, S.C. Schneider |
Pages | 416-419 |
Number of pages | 4 |
Volume | 1 |
State | Published - 2003 |
Event | 2003 IEEE Ultrasonics Symposium - Proceedings - Honolulu, HI, United States Duration: Oct 5 2003 → Oct 8 2003 |
Other
Other | 2003 IEEE Ultrasonics Symposium - Proceedings |
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Country/Territory | United States |
City | Honolulu, HI |
Period | 10/5/03 → 10/8/03 |
ASJC Scopus subject areas
- Engineering(all)