Detection of polymer-shelled ultrasound contrast agents using a signal subtraction method

Susannah H. Bloch, Divia N. Patel, Paul A. Dayton, Mingxi Wan, Katherine W. Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Polymer-shelled contrast agents demonstrate unique properties because the enclosed gas oscillates freely only after the shell is damaged. We have observed this behavior optically using a high-speed camera, and hypothesize that it leads to the observed acoustical property that the response of a polymer-shelled bubble to a two-pulse sequence depends on the order of pulse transmission. We have observed this property in two different polymer-shelled contrast agents. Based on these findings, we designed a pulse sequence to detect polymer-shelled bubbles, "signal subtraction," in which two same-phase single-cycle pulses are transmitted in succession and the resulting echoes subtracted. This subtraction results in the cancellation of tissue echoes, even in the presence of tissue harmonic generation, with only a small reduction in bubble signal amplitude.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE Ultrasonics Symposium
EditorsD.E. Yuhas, S.C. Schneider
Pages416-419
Number of pages4
Volume1
StatePublished - 2003
Event2003 IEEE Ultrasonics Symposium - Proceedings - Honolulu, HI, United States
Duration: Oct 5 2003Oct 8 2003

Other

Other2003 IEEE Ultrasonics Symposium - Proceedings
CountryUnited States
CityHonolulu, HI
Period10/5/0310/8/03

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Bloch, S. H., Patel, D. N., Dayton, P. A., Wan, M., & Ferrara, K. W. (2003). Detection of polymer-shelled ultrasound contrast agents using a signal subtraction method. In D. E. Yuhas, & S. C. Schneider (Eds.), Proceedings of the IEEE Ultrasonics Symposium (Vol. 1, pp. 416-419)