Detection of polymer-shelled ultrasound contrast agents using a signal subtraction method

Susannah H. Bloch; Divia N. Patel; Paul A. Dayton; Mingxi Wan; Katherine W. Ferrara

Detection of polymer-shelled ultrasound contrast agents using a signal subtraction method

Susannah H. Bloch, Divia N. Patel, Paul A. Dayton, Mingxi Wan, Katherine W. Ferrara

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Polymer-shelled contrast agents demonstrate unique properties because the enclosed gas oscillates freely only after the shell is damaged. We have observed this behavior optically using a high-speed camera, and hypothesize that it leads to the observed acoustical property that the response of a polymer-shelled bubble to a two-pulse sequence depends on the order of pulse transmission. We have observed this property in two different polymer-shelled contrast agents. Based on these findings, we designed a pulse sequence to detect polymer-shelled bubbles, "signal subtraction," in which two same-phase single-cycle pulses are transmitted in succession and the resulting echoes subtracted. This subtraction results in the cancellation of tissue echoes, even in the presence of tissue harmonic generation, with only a small reduction in bubble signal amplitude.

Original language	English (US)
Title of host publication	Proceedings of the IEEE Ultrasonics Symposium
Editors	D.E. Yuhas, S.C. Schneider
Pages	416-419
Number of pages	4
Volume	1
State	Published - 2003
Event	2003 IEEE Ultrasonics Symposium - Proceedings - Honolulu, HI, United States Duration: Oct 5 2003 → Oct 8 2003

Other

Other	2003 IEEE Ultrasonics Symposium - Proceedings
Country	United States
City	Honolulu, HI
Period	10/5/03 → 10/8/03

ASJC Scopus subject areas

Engineering(all)

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Detection of polymer-shelled ultrasound contrast agents using a signal subtraction method. / Bloch, Susannah H.; Patel, Divia N.; Dayton, Paul A.; Wan, Mingxi; Ferrara, Katherine W.

Proceedings of the IEEE Ultrasonics Symposium. ed. / D.E. Yuhas; S.C. Schneider. Vol. 1 2003. p. 416-419.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AB - Polymer-shelled contrast agents demonstrate unique properties because the enclosed gas oscillates freely only after the shell is damaged. We have observed this behavior optically using a high-speed camera, and hypothesize that it leads to the observed acoustical property that the response of a polymer-shelled bubble to a two-pulse sequence depends on the order of pulse transmission. We have observed this property in two different polymer-shelled contrast agents. Based on these findings, we designed a pulse sequence to detect polymer-shelled bubbles, "signal subtraction," in which two same-phase single-cycle pulses are transmitted in succession and the resulting echoes subtracted. This subtraction results in the cancellation of tissue echoes, even in the presence of tissue harmonic generation, with only a small reduction in bubble signal amplitude.

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