Detection of polymer-shelled ultrasound contrast agents using a signal subtraction method

Susannah H. Bloch, Divia N. Patel, Paul A. Dayton, Mingxi Wan, Katherine W. Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Polymer-shelled contrast agents demonstrate unique properties because the enclosed gas oscillates freely only after the shell is damaged. We have observed this behavior optically using a high-speed camera, and hypothesize that it leads to the observed acoustical property that the response of a polymer-shelled bubble to a two-pulse sequence depends on the order of pulse transmission. We have observed this property in two different polymer-shelled contrast agents. Based on these findings, we designed a pulse sequence to detect polymer-shelled bubbles, "signal subtraction," in which two same-phase single-cycle pulses are transmitted in succession and the resulting echoes subtracted. This subtraction results in the cancellation of tissue echoes, even in the presence of tissue harmonic generation, with only a small reduction in bubble signal amplitude.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE Ultrasonics Symposium
EditorsD.E. Yuhas, S.C. Schneider
Number of pages4
StatePublished - 2003
Event2003 IEEE Ultrasonics Symposium - Proceedings - Honolulu, HI, United States
Duration: Oct 5 2003Oct 8 2003


Other2003 IEEE Ultrasonics Symposium - Proceedings
Country/TerritoryUnited States
CityHonolulu, HI

ASJC Scopus subject areas

  • Engineering(all)


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