Detection of new diagnostic markers in pathology by focus on growth-regulatory endogenous lectins. The case study of galectin-7 in squamous epithelia.

M. Chovanec, K. Smetana, J. Plzák, J. Betka, Z. Plzáková, J. Stork, E. Hrdlicková, I. Kuwabara, B. Dvoránková, Fu-Tong Liu, H. Kaltner, S. André, H. J. Gabius

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Abstract

Lectins represent one of pivotal regulators of the cell proliferation The potential of galectin-7 as a new prognostic marker was studied in normal and transformed squamous epithelia of both ectodermal (epidermis, cornea vs. trichoepithelioma, basal and squamous cell carcinoma) and endodermal (vocal fold epithelium vs. carcinoma) origin. Studies on the cultured cells were also performed. Expression of galectin-7 seems to be connected to the process of stratification, no matter of origin of epithelium. Its expression is significantly reduced in malignant cells, thus galectin-7 might be a differentiation marker of epithelial malignancies.

Original languageEnglish (US)
Pages (from-to)209-216
Number of pages8
JournalPrague medical report
Volume106
Issue number2
StatePublished - 2005
Externally publishedYes

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Chovanec, M., Smetana, K., Plzák, J., Betka, J., Plzáková, Z., Stork, J., Hrdlicková, E., Kuwabara, I., Dvoránková, B., Liu, F-T., Kaltner, H., André, S., & Gabius, H. J. (2005). Detection of new diagnostic markers in pathology by focus on growth-regulatory endogenous lectins. The case study of galectin-7 in squamous epithelia. Prague medical report, 106(2), 209-216.