Detection of formation and disintegration of micelles by oblique-incidence reflectivity difference microscopy

Yung Shin Sun, Juntao Luo, Kit Lam, X. D. Zhu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

An oblique-incidence reflectivity difference (OI-RD) scanning microscope was developed for label-free detection of the formation and disintegration of micelles upon solid substrates. Micelles are made of polymers with hydrophilic heads in contact with the surrounding solvent and hydrophobic tails in the micelle center. This characteristic makes them very efficient drug carriers. Streptavidin molecules were first printed on glass slides for capturing biotinylated polymers. Micelles were formed when the concentration of polymers was higher than a critical value. The formation of micelles resulted in an increase in the oblique-incidence reflectivity difference signals. As the concentration of polymers decreased below the critical value, micelles were disintegrated, and a corresponding decrease in the oblique-incidence reflectivity difference signals was observed. This microscope was employed for the real-time monitoring of the formation and disintegration of two different micelles. The critical concentration above which micelles were formed was determined to be around 0.0006 mg-mL for micelles made of PEG5KCA8 polymers. The results suggest that this microscope would have practical application in testing the efficiency and durability of micellar drug carriers.

Original languageEnglish (US)
Pages (from-to)545-555
Number of pages11
JournalInstrumentation Science and Technology
Volume41
Issue number6
DOIs
StatePublished - Nov 2 2013

Fingerprint

Disintegration
Micelles
disintegration
reflectivity
microscopy
micelles
Microscopic examination
polymer
incidence
reflectance
Polymers
drug
Drug Carriers
Microscopes
microscopes
polymers
durability
drugs
glass
detection

Keywords

  • critical concentration
  • drug carrier
  • micelle
  • oblique-incidence reflectivity difference microscope

ASJC Scopus subject areas

  • Instrumentation
  • Chemical Engineering(all)
  • Environmental Science(all)

Cite this

Detection of formation and disintegration of micelles by oblique-incidence reflectivity difference microscopy. / Sun, Yung Shin; Luo, Juntao; Lam, Kit; Zhu, X. D.

In: Instrumentation Science and Technology, Vol. 41, No. 6, 02.11.2013, p. 545-555.

Research output: Contribution to journalArticle

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