Detection of feline herpesvirus 1 DNA in skin biopsy specimens from cats with or without dermatitis

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17 Scopus citations

Abstract

Objective - To compare detection rates of feline herpesvirus 1 (FHV-1) DNA in skin biopsy specimens from cats with herpetic dermatitis, cats with nonherpetic dermatitis, and cats without dermatitis. Design - Prevalence survey. Animals - 5 cats (9 biopsy specimens) with herpetic ulcerative dermatitis, 14 cats (17 biopsy specimens) with nonherpetic ulcerative dermatitis, and 8 cats (21 biopsy specimens) without clinically apparent skin lesions. Procedures - A single-phase PCR assay was used to detect FHV-1 DNA in biopsy specimens. Assay results were compared with results of histologic examination. Results - FHV-1 DNA was detected in all 9 biopsy specimens from the 5 cats with herpetic dermatitis and in 1 of 17 biopsy specimens from the 14 cats with nonherpetic dermatitis, but was not detected in any of the 21 biopsy specimens from the 8 cats without dermatitis. When results of histologic examination were used as the gold standard, sensitivity and specificity of the PCR assay were 100% and 95%, respectively. Conclusions and Clinical Relevance - Results confirmed that FHV-1 DNA can be detected in the skin of cats with herpetic dermatitis and suggest that the virus may play a causative role in the disease. In addition, the PCR assay may be useful in confirming a diagnosis of herpetic dermatitis.

Original languageEnglish (US)
Pages (from-to)1442-1446
Number of pages5
JournalJournal of the American Veterinary Medical Association
Volume229
Issue number9
DOIs
StatePublished - Nov 1 2006

ASJC Scopus subject areas

  • veterinary(all)

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