Detection of experimental brain tumors using time-resolved laser-induced fluorescence spectroscopy

Reid C. Thompson, Keith L. Black, Babek Kateb, Laura Marcu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations


Time-Resolved Laser-Induced Fluorescence Spectroscopy (TR-LIFS) has the potential to provide a non-invasive characterization and detection of tumors. We utilized TR-LIFS to detect gliomas in-vivo in the rat C6 glioma model. Time-resolved emission spectra of both normal brain and tumor were analyzed to determine if unique fluorescence signatures could be used to distinguish the two. Fluorescence parameters derived from both spectral and time domain were used for tissue characterization. Our results show that in the rat C6 glioma model, TR-LIFS can be used to differentiate brain tumors from normal tissue (gray and white mater) based upon time-resolved fluorescence signatures seen in brain tumors.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Number of pages5
StatePublished - 2002
EventOptical Biopsy IV - San Jose, CA, United States
Duration: Jan 21 2002Jan 23 2002


OtherOptical Biopsy IV
Country/TerritoryUnited States
CitySan Jose, CA


  • Brain tumor
  • Glioma rat model
  • Spectroscopy
  • Time-resolved laser induced fluorescence

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics


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