The application of nuclear magnetic resonance (NMR) spectroscopy to the analysis of tissue samples is often complicated by the presence of interfering signals. A plasma metabolite of considerable biological significance is βhydroxy-butyrate (βHB), which can reflect altered lipid and carbohydrate metabolism. Direct measurement of βHB in plasma via NMR is nullified by the presence of predominating lipid signals. The present study reports the successful application of a spectral editing sequence to measure elevated plasma βHB levels in fasted and alloxan-treated hamsters.
- Nuclear magnetic resonance
ASJC Scopus subject areas
- Health, Toxicology and Mutagenesis