Detection of echoes from adherent targeted microbubbles

Shukui Zhao; Dustin E. Kruse; Katherine W. Ferrara; Paul A. Dayton

doi:10.1109/ULTSYM.2006.137

Detection of echoes from adherent targeted microbubbles

Shukui Zhao, Dustin E. Kruse, Katherine W. Ferrara, Paul A. Dayton

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Citations (Scopus)

Abstract

A challenging task in ultrasonic molecular imaging is to detect the echoes from microbubbles that are tethered to a vessel wall by targeting ligands, and distinguish them from echoes from flowing agents and tissue. By combining optical and acoustical experimental systems, a protocol was developed to force targeted microbubbles to bind to a phantom vessel wall with the binding verified optically and the echo recorded acoustically. Differences in the acoustical response between free and bound contrast agents were observed and mechanisms for these differences were proposed. The observed acoustical difference can be utilized for a new selective detection method for adherent microbubbles.

Original language	English (US)
Title of host publication	Proceedings - IEEE Ultrasonics Symposium
Pages	525-528
Number of pages	4
Volume	1
DOIs	https://doi.org/10.1109/ULTSYM.2006.137
State	Published - 2006

Fingerprint

echoes

vessels

ultrasonics

ligands

Keywords

Microbubbles
Targeted contrast agents
Ultrasonic molecular imaging

ASJC Scopus subject areas

Acoustics and Ultrasonics

Cite this

Zhao, S., Kruse, D. E., Ferrara, K. W., & Dayton, P. A. (2006). Detection of echoes from adherent targeted microbubbles. In Proceedings - IEEE Ultrasonics Symposium (Vol. 1, pp. 525-528). [4151993] https://doi.org/10.1109/ULTSYM.2006.137

Detection of echoes from adherent targeted microbubbles. / Zhao, Shukui; Kruse, Dustin E.; Ferrara, Katherine W.; Dayton, Paul A.

Proceedings - IEEE Ultrasonics Symposium. Vol. 1 2006. p. 525-528 4151993.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Zhao, S, Kruse, DE, Ferrara, KW & Dayton, PA 2006, Detection of echoes from adherent targeted microbubbles. in Proceedings - IEEE Ultrasonics Symposium. vol. 1, 4151993, pp. 525-528. https://doi.org/10.1109/ULTSYM.2006.137

Zhao S, Kruse DE, Ferrara KW, Dayton PA. Detection of echoes from adherent targeted microbubbles. In Proceedings - IEEE Ultrasonics Symposium. Vol. 1. 2006. p. 525-528. 4151993 https://doi.org/10.1109/ULTSYM.2006.137

Zhao, Shukui ; Kruse, Dustin E. ; Ferrara, Katherine W. ; Dayton, Paul A. / Detection of echoes from adherent targeted microbubbles. Proceedings - IEEE Ultrasonics Symposium. Vol. 1 2006. pp. 525-528

@inproceedings{c44920b9ce4d4fdaa50f9c0a04c52b96,

title = "Detection of echoes from adherent targeted microbubbles",

abstract = "A challenging task in ultrasonic molecular imaging is to detect the echoes from microbubbles that are tethered to a vessel wall by targeting ligands, and distinguish them from echoes from flowing agents and tissue. By combining optical and acoustical experimental systems, a protocol was developed to force targeted microbubbles to bind to a phantom vessel wall with the binding verified optically and the echo recorded acoustically. Differences in the acoustical response between free and bound contrast agents were observed and mechanisms for these differences were proposed. The observed acoustical difference can be utilized for a new selective detection method for adherent microbubbles.",

keywords = "Microbubbles, Targeted contrast agents, Ultrasonic molecular imaging",

author = "Shukui Zhao and Kruse, {Dustin E.} and Ferrara, {Katherine W.} and Dayton, {Paul A.}",

year = "2006",

doi = "10.1109/ULTSYM.2006.137",

language = "English (US)",

isbn = "1424402018",

volume = "1",

pages = "525--528",

booktitle = "Proceedings - IEEE Ultrasonics Symposium",

}

TY - GEN

T1 - Detection of echoes from adherent targeted microbubbles

AU - Zhao, Shukui

AU - Kruse, Dustin E.

AU - Ferrara, Katherine W.

AU - Dayton, Paul A.

PY - 2006

Y1 - 2006

N2 - A challenging task in ultrasonic molecular imaging is to detect the echoes from microbubbles that are tethered to a vessel wall by targeting ligands, and distinguish them from echoes from flowing agents and tissue. By combining optical and acoustical experimental systems, a protocol was developed to force targeted microbubbles to bind to a phantom vessel wall with the binding verified optically and the echo recorded acoustically. Differences in the acoustical response between free and bound contrast agents were observed and mechanisms for these differences were proposed. The observed acoustical difference can be utilized for a new selective detection method for adherent microbubbles.

AB - A challenging task in ultrasonic molecular imaging is to detect the echoes from microbubbles that are tethered to a vessel wall by targeting ligands, and distinguish them from echoes from flowing agents and tissue. By combining optical and acoustical experimental systems, a protocol was developed to force targeted microbubbles to bind to a phantom vessel wall with the binding verified optically and the echo recorded acoustically. Differences in the acoustical response between free and bound contrast agents were observed and mechanisms for these differences were proposed. The observed acoustical difference can be utilized for a new selective detection method for adherent microbubbles.

KW - Microbubbles

KW - Targeted contrast agents

KW - Ultrasonic molecular imaging

UR - http://www.scopus.com/inward/record.url?scp=78649382954&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649382954&partnerID=8YFLogxK

U2 - 10.1109/ULTSYM.2006.137

DO - 10.1109/ULTSYM.2006.137

M3 - Conference contribution

AN - SCOPUS:78649382954

SN - 1424402018

SN - 9781424402014

VL - 1

SP - 525

EP - 528

BT - Proceedings - IEEE Ultrasonics Symposium

ER -

Access to Document

10.1109/ULTSYM.2006.137