TY - GEN
T1 - Detection of echoes from adherent targeted microbubbles
AU - Zhao, Shukui
AU - Kruse, Dustin E.
AU - Ferrara, Katherine W.
AU - Dayton, Paul A.
PY - 2006
Y1 - 2006
N2 - A challenging task in ultrasonic molecular imaging is to detect the echoes from microbubbles that are tethered to a vessel wall by targeting ligands, and distinguish them from echoes from flowing agents and tissue. By combining optical and acoustical experimental systems, a protocol was developed to force targeted microbubbles to bind to a phantom vessel wall with the binding verified optically and the echo recorded acoustically. Differences in the acoustical response between free and bound contrast agents were observed and mechanisms for these differences were proposed. The observed acoustical difference can be utilized for a new selective detection method for adherent microbubbles.
AB - A challenging task in ultrasonic molecular imaging is to detect the echoes from microbubbles that are tethered to a vessel wall by targeting ligands, and distinguish them from echoes from flowing agents and tissue. By combining optical and acoustical experimental systems, a protocol was developed to force targeted microbubbles to bind to a phantom vessel wall with the binding verified optically and the echo recorded acoustically. Differences in the acoustical response between free and bound contrast agents were observed and mechanisms for these differences were proposed. The observed acoustical difference can be utilized for a new selective detection method for adherent microbubbles.
KW - Microbubbles
KW - Targeted contrast agents
KW - Ultrasonic molecular imaging
UR - http://www.scopus.com/inward/record.url?scp=78649382954&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78649382954&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2006.137
DO - 10.1109/ULTSYM.2006.137
M3 - Conference contribution
AN - SCOPUS:78649382954
SN - 1424402018
SN - 9781424402014
VL - 1
SP - 525
EP - 528
BT - Proceedings - IEEE Ultrasonics Symposium
ER -