Detection of dementia of the Alzheimer type in a population-based sample: Neuropsychological test performance

Deborah Cahn-Weiner, Nelson Butters, Deborah A. Cahn, David P. Salmon, Wigbert C. Wiederholt, Jody Corey-Bloom, Sharon L. Edelstein, Elizabeth Barrett-Connor

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

The ability to detect dementia of the Alzheimer type (DAT) in a community-dwelling sample of elderly individuals on the basis of neuropsychological test performance was examined. Three hundred sixty community-dwelling individuals were identified by neurological examination as having probable or possible Alzheimer's disease, being at risk for Alzheimer's disease, or having no cognitive impairment. A logistic model comprised of tests of verbal and nonverbal memory, mental flexibility, and confrontation naming correctly classified 82% of DAT subjects and 98% of normal elderly subjects. The logistic model classified 77% of subjects who were diagnosed as at risk for Alzheimer's disease as being cognitively normal. A cross-validation with a clinically based sample of subjects correctly classified 89% of DAT patients and 100% of normal control subjects. The results suggest that psychometric discrimination of dementia may be less accurate in community-dwelling populations than in clinically based samples. (JINS, 1995, 1, 252-260.).

Original languageEnglish (US)
Pages (from-to)252-260
Number of pages9
JournalJournal of the International Neuropsychological Society
Volume1
Issue number3
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Dementia
  • Neuropsychological testing

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

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