Detection and pharmacokinetics of three formulations of firocoxib following multiple administrations to horses

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Reason for performing study: The use of firocoxib in horses and its ability to affect performance and potential to allow a horse to compete when it otherwise should not, necessitates establishing appropriate withdrawal time guidelines prior to performance. Objectives: To describe plasma concentrations and characterise the pharmacokinetics of 3 firocoxib formulations following multiple administrations of the label dose, with respect to recommended plasma thresholds for performance horses. Study design: Balanced 3-way crossover prospective study. Methods: Nine healthy mature horses were administered firocoxib injectable solution (0.09mg/kg bwt i.v. s.i.d. for 5 days), firocoxib paste (0.1mg/kg bwt per os s.i.d. for 14 days) and firocoxib tablets (57mg s.i.d. for 14 days). Blood samples were collected at Time 0 and at various times post drug administration until plasma concentrations were below the limit of detection of the assay. Plasma samples were analysed using liquid chromatography-mass spectrometry and data analysed using noncompartmental analysis. Results: The mean plasma half-life was 1.64 ± 0.737, 1.70 ± 0.800 and 1.73 ± 0.767 days for injectable, paste and tablet formulations, respectively. Plasma concentrations fell below the Racing Medication and Testing Consortium's recommended threshold for racehorses (20ng/ml) by 7 days post administration of the final dose for all formulations. Plasma concentrations never exceeded the threshold concentration (240ng/ml) for horse competing in US Equestrian Federation events for any of the formulations. Conclusions: This study extends current knowledge regarding the pharmacokinetics of firocoxib and provides information that can be used to establish appropriate withdrawal time guidelines following multiple administrations, with respect to already established plasma regulatory threshold concentrations.

Original languageEnglish (US)
Pages (from-to)734-738
Number of pages5
JournalEquine Veterinary Journal
Volume46
Issue number6
DOIs
StatePublished - Nov 1 2014

Keywords

  • Firocoxib
  • Horse
  • Performance horse
  • Pharmacokinetics
  • Racehorse
  • Threshold

ASJC Scopus subject areas

  • Equine

Fingerprint Dive into the research topics of 'Detection and pharmacokinetics of three formulations of firocoxib following multiple administrations to horses'. Together they form a unique fingerprint.

  • Cite this