Detecting single bacterial cells through optical resonances in microdroplets

Melikhan Tanyeri, Ian M. Kennedy

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Detection of single bacterial cells through optical resonances has been demonstrated in microdroplets. The setup enables high throughput non-specific detection of single E. Coli cells without any labeling. The cells inside the microdroplet have a direct effect on the morphology dependent resonances that are supported by Rhodamine 6G fluorescence; modification of the resonances arises from changes due to scattering and changes in the local refractive index. The change in the optical resonance spectrum can be observed at low concentrations where each microdroplet contains no more than one cell.

Original languageEnglish (US)
Pages (from-to)326-329
Number of pages4
JournalSensor Letters
Volume6
Issue number2
DOIs
StatePublished - Apr 2008

Keywords

  • Biosensor
  • E. Coli
  • Microdroplet
  • Morphology dependent resonances (MDRs)

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics

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