Detecting hypoglycemia in venous blood: Comparison of two neonatal bedside glucose monitors

David S. Louder, Stephen L. Mikkelsen, Donald Null

Research output: Contribution to journalArticlepeer-review


We evaluated the performance of the One Touch II Hospital in neonatal mode (Lifescan, Militipas, Calif) and Accu-Chek II (Boehringer Mannheim, Indianapolis) in screening for neonatal hypoglycemia. We used blood with low- to-normal glucose concentrations and a wide range of hematocrits to mimic infant blood. Single-donor adult blood was collected in heparinized tubes and allowed to metabolize overnight. Red blood cells were separated and reconstituted with the plasma, normal saline, and 10% dextrose to 5 hematocrits and 6 approximate plasma glucose concentrations. All 30 combinations of hematocrit and glucose concentration were tested. The One Touch II Hospital glucose monitor showed the best accuracy of numeric results (32%-78% vs 11%-54%), precision (pooled standard deviation, 1.4 mg/dL vs 4.6- 13.9 mg/dL), and correlation (Pearson's r, 0.95-0.98 vs 0.82-0.86). Sensitivity and specificity for hypoglycemic glucose levels were statistically similar.

Original languageEnglish (US)
Pages (from-to)184-187
Number of pages4
JournalLaboratory Medicine
Issue number3
StatePublished - Jan 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical


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