Abstract
Neonatal and postnatal exposures to air pollutants have adverse effects on lung development resulting in airway structure changes. Usually, generation-averaged analysis of airway geometric parameters is employed to differentiate between pulmonary airway trees. However, this method is limited, especially for monopodial branching trees such as in rat airways, because both quite proximal and less proximal airways that have very different structure and function may be in the same generation. To avoid limitations inherent in generation averaging, we developed a method that compares two trees airway-by-airway using micro CT image data from rat lungs. This computerized technique (1) identifies the geometry and architecture of the conducting airways from CT images, (2) extracts the main tree, (3) associates paired airways from the two different trees, and (4) develops summary statistics on the degree of similarity between populations of animals. By comparing the trees airway-by-airway, we found that the variance in airway length of the group exposed to diffusion flame particles (DFP) is significantly larger than the group raised in filtered air (FA). This method also found that rotation angle of the DFP group is significantly larger than FA, which is not as certain in the generation-based analysis. We suggest that airway-by-airway analysis complements generation-based averaging for detecting airway alterations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1805-1814 |
| Number of pages | 10 |
| Journal | Annals of Biomedical Engineering |
| Volume | 39 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2011 |
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Keywords
- Airway-by-airway comparison
- CT image
- Development disruption
- Diffusion flame particles
- Pulmonary airways
- Rat lungs
ASJC Scopus subject areas
- Biomedical Engineering
Cite this
Detecting alterations in pulmonary airway development with airway-by-airway comparison. / Lee, Dongyoub; Willits, Neil; Wexler, Anthony S.
In: Annals of Biomedical Engineering, Vol. 39, No. 6, 06.2011, p. 1805-1814.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Detecting alterations in pulmonary airway development with airway-by-airway comparison
AU - Lee, Dongyoub
AU - Willits, Neil
AU - Wexler, Anthony S.
PY - 2011/6
Y1 - 2011/6
N2 - Neonatal and postnatal exposures to air pollutants have adverse effects on lung development resulting in airway structure changes. Usually, generation-averaged analysis of airway geometric parameters is employed to differentiate between pulmonary airway trees. However, this method is limited, especially for monopodial branching trees such as in rat airways, because both quite proximal and less proximal airways that have very different structure and function may be in the same generation. To avoid limitations inherent in generation averaging, we developed a method that compares two trees airway-by-airway using micro CT image data from rat lungs. This computerized technique (1) identifies the geometry and architecture of the conducting airways from CT images, (2) extracts the main tree, (3) associates paired airways from the two different trees, and (4) develops summary statistics on the degree of similarity between populations of animals. By comparing the trees airway-by-airway, we found that the variance in airway length of the group exposed to diffusion flame particles (DFP) is significantly larger than the group raised in filtered air (FA). This method also found that rotation angle of the DFP group is significantly larger than FA, which is not as certain in the generation-based analysis. We suggest that airway-by-airway analysis complements generation-based averaging for detecting airway alterations.
AB - Neonatal and postnatal exposures to air pollutants have adverse effects on lung development resulting in airway structure changes. Usually, generation-averaged analysis of airway geometric parameters is employed to differentiate between pulmonary airway trees. However, this method is limited, especially for monopodial branching trees such as in rat airways, because both quite proximal and less proximal airways that have very different structure and function may be in the same generation. To avoid limitations inherent in generation averaging, we developed a method that compares two trees airway-by-airway using micro CT image data from rat lungs. This computerized technique (1) identifies the geometry and architecture of the conducting airways from CT images, (2) extracts the main tree, (3) associates paired airways from the two different trees, and (4) develops summary statistics on the degree of similarity between populations of animals. By comparing the trees airway-by-airway, we found that the variance in airway length of the group exposed to diffusion flame particles (DFP) is significantly larger than the group raised in filtered air (FA). This method also found that rotation angle of the DFP group is significantly larger than FA, which is not as certain in the generation-based analysis. We suggest that airway-by-airway analysis complements generation-based averaging for detecting airway alterations.
KW - Airway-by-airway comparison
KW - CT image
KW - Development disruption
KW - Diffusion flame particles
KW - Pulmonary airways
KW - Rat lungs
UR - http://www.scopus.com/inward/record.url?scp=79958781921&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958781921&partnerID=8YFLogxK
U2 - 10.1007/s10439-011-0279-4
DO - 10.1007/s10439-011-0279-4
M3 - Article
C2 - 21347548
AN - SCOPUS:79958781921
VL - 39
SP - 1805
EP - 1814
JO - Annals of Biomedical Engineering
JF - Annals of Biomedical Engineering
SN - 0090-6964
IS - 6
ER -