Desmoplastic cerebral astrocytoma of infancy - A case report with immunohistochemical, ultrastructural and proliferation studies

Faruk Aydin, Nitya R. Ghatak, Jack Salvant, Jan Paul Muizelaar

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

We present a case of desmoplastic cerebral astrocytoma of infancy (DCAI) in a 7 1/2-month-old girl and include immunohistochemical, ultrastructural and proliferative activity studies. The dural-based cystic tumor showed a biphasic pattern consisting of glial fibrillary acidic protein (GFAP)-positive astrocytes embedded in a desmoplastic stroma. The astrocytic processes were lined with basal lamina at their surface contacting the collagen. Scattered islands of undifferentiated small cells were seen acquiring GFAP positivity at their peripheral zone facing the collagen. Studies with silver nucleolar organizer region and proliferating cell nuclear antigen disclosed a high proliferative activity. Flow cytometric study showed an elevated S phase and 15% hypertetraploid cell population. These findings contrast the favorable prognosis of the tumor at 26 months follow-up. Probably, extracellular-matrix-induced maturation of the undifferentiated cells with the formation of basal lamina may account for this unique disparity.

Original languageEnglish (US)
Pages (from-to)666-670
Number of pages5
JournalActa Neuropathologica
Volume86
Issue number6
DOIs
StatePublished - Nov 1993
Externally publishedYes

Keywords

  • Astrocytoma
  • Cyst
  • Desmoplasia
  • Dura
  • Infant

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

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