Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase

Stevan Pecic, Shi Xian Deng, Christophe Morisseau, Bruce D. Hammock, Donald W. Landry

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Inhibition of soluble epoxide hydrolase (sEH) has been proposed as a new pharmaceutical approach for treating hypertension and vascular inflammation. The most potent sEH inhibitors reported in literature to date are urea derivatives. However, these compounds have limited pharmacokinetic profiles. We investigated non-urea amide derivatives as sEH inhibitors and identified a potent human sEH inhibitor 14-34 having potency comparable to urea-based inhibitors.

Original languageEnglish (US)
Pages (from-to)601-605
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number1
DOIs
StatePublished - Jan 1 2012

Fingerprint

Epoxide Hydrolases
Urea
Derivatives
Pharmacokinetics
Amides
Blood Vessels
Hypertension
Inflammation
Pharmaceutical Preparations

Keywords

  • Anti-inflamatory
  • Hypertension
  • Non-urea inhibitors
  • sEH
  • Soluble epoxide hydrolase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase. / Pecic, Stevan; Deng, Shi Xian; Morisseau, Christophe; Hammock, Bruce D.; Landry, Donald W.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 22, No. 1, 01.01.2012, p. 601-605.

Research output: Contribution to journalArticle

Pecic, Stevan ; Deng, Shi Xian ; Morisseau, Christophe ; Hammock, Bruce D. ; Landry, Donald W. / Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase. In: Bioorganic and Medicinal Chemistry Letters. 2012 ; Vol. 22, No. 1. pp. 601-605.
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