Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase

Stevan Pecic, Shi Xian Deng, Christophe Morisseau, Bruce D. Hammock, Donald W. Landry

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Inhibition of soluble epoxide hydrolase (sEH) has been proposed as a new pharmaceutical approach for treating hypertension and vascular inflammation. The most potent sEH inhibitors reported in literature to date are urea derivatives. However, these compounds have limited pharmacokinetic profiles. We investigated non-urea amide derivatives as sEH inhibitors and identified a potent human sEH inhibitor 14-34 having potency comparable to urea-based inhibitors.

Original languageEnglish (US)
Pages (from-to)601-605
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number1
StatePublished - Jan 1 2012


  • Anti-inflamatory
  • Hypertension
  • Non-urea inhibitors
  • sEH
  • Soluble epoxide hydrolase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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