Abstract
A novel polyazacyclophane hexa-amine (1) has been designed, synthesized and characterized by X-ray crystallography, 1H NMR and fluorescence spectroscopy. 1 has the structural shape and disposition of charges complementary to the major groove of B-DNA. Acid dissociation constants for the protonated 1 were pK(a1)(D) = 4.8 and pK(a2)(D) = 8.5. Equilibrium constants for the binding of 1 to ctDNA and T4 DNA were 1.2 x 105 and 1.8 x 106, respectively.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8105-8120 |
| Number of pages | 16 |
| Journal | Tetrahedron |
| Volume | 53 |
| Issue number | 24 |
| DOIs | |
| State | Published - Jun 16 1997 |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
Fingerprint Dive into the research topics of 'Design, synthesis, and characterization of a novel hexa-azacyclophane and interactions with d(CGCA<sub>3</sub>T<sub>3</sub>GCG)<sub>2</sub>, ctDNA and T4DNA'. Together they form a unique fingerprint.
Cite this
Bruice, T. C., Yip, Y. C., Blaskó, A., Lightstone, F. C., Browne, K. A., Petyak, M. E., & Luo, J. (1997). Design, synthesis, and characterization of a novel hexa-azacyclophane and interactions with d(CGCA3T3GCG)2, ctDNA and T4DNA. Tetrahedron, 53(24), 8105-8120. https://doi.org/10.1016/S0040-4020(97)00501-2