Abstract
A novel polyazacyclophane hexa-amine (1) has been designed, synthesized and characterized by X-ray crystallography, 1H NMR and fluorescence spectroscopy. 1 has the structural shape and disposition of charges complementary to the major groove of B-DNA. Acid dissociation constants for the protonated 1 were pK(a1)(D) = 4.8 and pK(a2)(D) = 8.5. Equilibrium constants for the binding of 1 to ctDNA and T4 DNA were 1.2 x 105 and 1.8 x 106, respectively.
Original language | English (US) |
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Pages (from-to) | 8105-8120 |
Number of pages | 16 |
Journal | Tetrahedron |
Volume | 53 |
Issue number | 24 |
DOIs | |
State | Published - Jun 16 1997 |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery