Abstract
Regulation by a repressor protein is the mechanism selected when, in the organism's natural environment, there is low demand for expression of the regulated structural genes. Regulation by an activator protein is selected when there is high demand for expression of the regulated structural genes. These general conclusions are useful in relating physiological function to underlying molecular determinants in a wide variety of systems that includes repressible biosynthetic pathways, inducible biosynthetic enzymes, inducible drug resistance, and prophage induction, as well as inducible catabolic pathways, for which a special case of this prediction previously was reported [Savageau, M. A. (1974) Proc. Natl. Acad. Sci. USA 71, 2453-2455].
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5647-5651 |
| Number of pages | 5 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 74 |
| Issue number | 12 |
| State | Published - Dec 1977 |
| Externally published | Yes |
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ASJC Scopus subject areas
- General
- Genetics
Cite this
Design of molecular control mechanisms and the demand for gene expression. / Savageau, M. A.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 74, No. 12, 12.1977, p. 5647-5651.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Design of molecular control mechanisms and the demand for gene expression.
AU - Savageau, M. A.
PY - 1977/12
Y1 - 1977/12
N2 - Regulation by a repressor protein is the mechanism selected when, in the organism's natural environment, there is low demand for expression of the regulated structural genes. Regulation by an activator protein is selected when there is high demand for expression of the regulated structural genes. These general conclusions are useful in relating physiological function to underlying molecular determinants in a wide variety of systems that includes repressible biosynthetic pathways, inducible biosynthetic enzymes, inducible drug resistance, and prophage induction, as well as inducible catabolic pathways, for which a special case of this prediction previously was reported [Savageau, M. A. (1974) Proc. Natl. Acad. Sci. USA 71, 2453-2455].
AB - Regulation by a repressor protein is the mechanism selected when, in the organism's natural environment, there is low demand for expression of the regulated structural genes. Regulation by an activator protein is selected when there is high demand for expression of the regulated structural genes. These general conclusions are useful in relating physiological function to underlying molecular determinants in a wide variety of systems that includes repressible biosynthetic pathways, inducible biosynthetic enzymes, inducible drug resistance, and prophage induction, as well as inducible catabolic pathways, for which a special case of this prediction previously was reported [Savageau, M. A. (1974) Proc. Natl. Acad. Sci. USA 71, 2453-2455].
UR - http://www.scopus.com/inward/record.url?scp=0017635932&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017635932&partnerID=8YFLogxK
M3 - Article
VL - 74
SP - 5647
EP - 5651
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 12
ER -