Design of molecular control mechanisms and the demand for gene expression.

M. A. Savageau

Research output: Contribution to journalArticle

80 Scopus citations


Regulation by a repressor protein is the mechanism selected when, in the organism's natural environment, there is low demand for expression of the regulated structural genes. Regulation by an activator protein is selected when there is high demand for expression of the regulated structural genes. These general conclusions are useful in relating physiological function to underlying molecular determinants in a wide variety of systems that includes repressible biosynthetic pathways, inducible biosynthetic enzymes, inducible drug resistance, and prophage induction, as well as inducible catabolic pathways, for which a special case of this prediction previously was reported [Savageau, M. A. (1974) Proc. Natl. Acad. Sci. USA 71, 2453-2455].

Original languageEnglish (US)
Pages (from-to)5647-5651
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number12
StatePublished - Dec 1977
Externally publishedYes


ASJC Scopus subject areas

  • General
  • Genetics

Cite this