Design of gene circuits: Lessons from bacteria

Michael E. Wall, William S. Hlavacek, Michael A. Savageau

Research output: Contribution to journalArticle

166 Scopus citations

Abstract

Researchers are now building synthetic circuits for controlling gene expression and considering practical applications for engineered gene circuits. What can we learn from nature about design principles for gene circuits? A large body of experimental data is now available to test some important theoretical predictions about how gene circuits could be organized, but the data also raise some intriguing new questions.

Original languageEnglish (US)
Pages (from-to)34-42
Number of pages9
JournalNature Reviews Genetics
Volume5
Issue number1
DOIs
StatePublished - Jan 2004

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)

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    Wall, M. E., Hlavacek, W. S., & Savageau, M. A. (2004). Design of gene circuits: Lessons from bacteria. Nature Reviews Genetics, 5(1), 34-42. https://doi.org/10.1038/nrg1244