Design of gene circuits: Lessons from bacteria

Michael E. Wall; William S. Hlavacek; Michael A. Savageau

doi:10.1038/nrg1244

Design of gene circuits: Lessons from bacteria

Michael E. Wall, William S. Hlavacek, Michael A. Savageau

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

178 Scopus citations

Abstract

Researchers are now building synthetic circuits for controlling gene expression and considering practical applications for engineered gene circuits. What can we learn from nature about design principles for gene circuits? A large body of experimental data is now available to test some important theoretical predictions about how gene circuits could be organized, but the data also raise some intriguing new questions.

Original language	English (US)
Pages (from-to)	34-42
Number of pages	9
Journal	Nature Reviews Genetics
Volume	5
Issue number	1
DOIs	https://doi.org/10.1038/nrg1244
State	Published - Jan 2004

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Genetics
Genetics(clinical)

Access to Document

10.1038/nrg1244

Cite this

@article{59543f9a0aee46899fd4a95220c70f7c,

title = "Design of gene circuits: Lessons from bacteria",

abstract = "Researchers are now building synthetic circuits for controlling gene expression and considering practical applications for engineered gene circuits. What can we learn from nature about design principles for gene circuits? A large body of experimental data is now available to test some important theoretical predictions about how gene circuits could be organized, but the data also raise some intriguing new questions.",

author = "Wall, {Michael E.} and Hlavacek, {William S.} and Savageau, {Michael A.}",

year = "2004",

month = jan,

doi = "10.1038/nrg1244",

language = "English (US)",

volume = "5",

pages = "34--42",

journal = "Nature Reviews Genetics",

issn = "1471-0056",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Design of gene circuits

T2 - Lessons from bacteria

AU - Wall, Michael E.

AU - Hlavacek, William S.

AU - Savageau, Michael A.

PY - 2004/1

Y1 - 2004/1

N2 - Researchers are now building synthetic circuits for controlling gene expression and considering practical applications for engineered gene circuits. What can we learn from nature about design principles for gene circuits? A large body of experimental data is now available to test some important theoretical predictions about how gene circuits could be organized, but the data also raise some intriguing new questions.

AB - Researchers are now building synthetic circuits for controlling gene expression and considering practical applications for engineered gene circuits. What can we learn from nature about design principles for gene circuits? A large body of experimental data is now available to test some important theoretical predictions about how gene circuits could be organized, but the data also raise some intriguing new questions.

UR - http://www.scopus.com/inward/record.url?scp=0346728474&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0346728474&partnerID=8YFLogxK

U2 - 10.1038/nrg1244

DO - 10.1038/nrg1244

M3 - Article

C2 - 14708014

AN - SCOPUS:0346728474

VL - 5

SP - 34

EP - 42

JO - Nature Reviews Genetics

JF - Nature Reviews Genetics

SN - 1471-0056

IS - 1

ER -

Design of gene circuits: Lessons from bacteria

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this