Design of gene circuits: Lessons from bacteria

Michael E. Wall; William S. Hlavacek; Michael A. Savageau

doi:10.1038/nrg1244

Design of gene circuits: Lessons from bacteria

Michael E. Wall, William S. Hlavacek, Michael A. Savageau

Biomedical Engineering

Research output: Contribution to journal › Article

166 Scopus citations

Abstract

Researchers are now building synthetic circuits for controlling gene expression and considering practical applications for engineered gene circuits. What can we learn from nature about design principles for gene circuits? A large body of experimental data is now available to test some important theoretical predictions about how gene circuits could be organized, but the data also raise some intriguing new questions.

Original language	English (US)
Pages (from-to)	34-42
Number of pages	9
Journal	Nature Reviews Genetics
Volume	5
Issue number	1
DOIs	https://doi.org/10.1038/nrg1244
State	Published - Jan 2004

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Genetics
Genetics(clinical)

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10.1038/nrg1244

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Wall, M. E., Hlavacek, W. S., & Savageau, M. A. (2004). Design of gene circuits: Lessons from bacteria. Nature Reviews Genetics, 5(1), 34-42. https://doi.org/10.1038/nrg1244

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