Design of gene circuits: Lessons from bacteria

Michael E. Wall, William S. Hlavacek, Michael A. Savageau

Research output: Contribution to journal › Article

164 Citations (Scopus)

Abstract

Researchers are now building synthetic circuits for controlling gene expression and considering practical applications for engineered gene circuits. What can we learn from nature about design principles for gene circuits? A large body of experimental data is now available to test some important theoretical predictions about how gene circuits could be organized, but the data also raise some intriguing new questions.

Original languageEnglish (US)
Pages (from-to)34-42
Number of pages9
JournalNature Reviews Genetics
Volume5
Issue number1
DOIs
StatePublished - Jan 2004

Fingerprint

Gene Regulatory Networks
Bacteria
bacteria
researchers
Research Personnel
Gene Expression
gene expression
prediction
gene regulatory networks
testing

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)

Cite this

Wall, M. E., Hlavacek, W. S., & Savageau, M. A. (2004). Design of gene circuits: Lessons from bacteria. Nature Reviews Genetics, 5(1), 34-42. https://doi.org/10.1038/nrg1244

Design of gene circuits : Lessons from bacteria. / Wall, Michael E.; Hlavacek, William S.; Savageau, Michael A.

In: Nature Reviews Genetics, Vol. 5, No. 1, 01.2004, p. 34-42.

Research output: Contribution to journal › Article

Wall, ME, Hlavacek, WS & Savageau, MA 2004, 'Design of gene circuits: Lessons from bacteria', Nature Reviews Genetics, vol. 5, no. 1, pp. 34-42. https://doi.org/10.1038/nrg1244
Wall ME, Hlavacek WS, Savageau MA. Design of gene circuits: Lessons from bacteria. Nature Reviews Genetics. 2004 Jan;5(1):34-42. https://doi.org/10.1038/nrg1244
Wall, Michael E. ; Hlavacek, William S. ; Savageau, Michael A. / Design of gene circuits : Lessons from bacteria. In: Nature Reviews Genetics. 2004 ; Vol. 5, No. 1. pp. 34-42.
@article{59543f9a0aee46899fd4a95220c70f7c,
title = "Design of gene circuits: Lessons from bacteria",
abstract = "Researchers are now building synthetic circuits for controlling gene expression and considering practical applications for engineered gene circuits. What can we learn from nature about design principles for gene circuits? A large body of experimental data is now available to test some important theoretical predictions about how gene circuits could be organized, but the data also raise some intriguing new questions.",
author = "Wall, {Michael E.} and Hlavacek, {William S.} and Savageau, {Michael A.}",
year = "2004",
month = "1",
doi = "10.1038/nrg1244",
language = "English (US)",
volume = "5",
pages = "34--42",
journal = "Nature Reviews Genetics",
issn = "1471-0056",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Design of gene circuits

T2 - Lessons from bacteria

AU - Wall, Michael E.

AU - Hlavacek, William S.

AU - Savageau, Michael A.

PY - 2004/1

Y1 - 2004/1

N2 - Researchers are now building synthetic circuits for controlling gene expression and considering practical applications for engineered gene circuits. What can we learn from nature about design principles for gene circuits? A large body of experimental data is now available to test some important theoretical predictions about how gene circuits could be organized, but the data also raise some intriguing new questions.

AB - Researchers are now building synthetic circuits for controlling gene expression and considering practical applications for engineered gene circuits. What can we learn from nature about design principles for gene circuits? A large body of experimental data is now available to test some important theoretical predictions about how gene circuits could be organized, but the data also raise some intriguing new questions.

UR - http://www.scopus.com/inward/record.url?scp=0346728474&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0346728474&partnerID=8YFLogxK

U2 - 10.1038/nrg1244

DO - 10.1038/nrg1244

M3 - Article

C2 - 14708014

AN - SCOPUS:0346728474

VL - 5

SP - 34

EP - 42

JO - Nature Reviews Genetics

JF - Nature Reviews Genetics

SN - 1471-0056

IS - 1

ER -

Access to Document