Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications

Paige J. Levalley, Elisa M. Ovadia, Christopher A. Bresette, Lisa A. Sawicki, Emanual Michael Maverakis, Shi Bai, April M. Kloxin

Research output: Contribution to journalArticle

Abstract

An approach for the design of functionalized cyclic peptides is established for use in 3D cell culture and in cell targeting. Sequential orthogonal click reactions, specifically a photoinitiated thiol-ene and strain promoted azide-alkyne cycloaddition, were utilized for peptide cyclization and conjugation relevant for biomaterial and biomedical applications, respectively.

Original languageEnglish (US)
Pages (from-to)6923-6926
Number of pages4
JournalChemical Communications
Volume54
Issue number50
DOIs
StatePublished - Jan 1 2018

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Cyclic Peptides
Alkynes
Azides
Cycloaddition
Cyclization
Biocompatible Materials
Cell culture
Sulfhydryl Compounds
Biomaterials
Peptides

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications. / Levalley, Paige J.; Ovadia, Elisa M.; Bresette, Christopher A.; Sawicki, Lisa A.; Maverakis, Emanual Michael; Bai, Shi; Kloxin, April M.

In: Chemical Communications, Vol. 54, No. 50, 01.01.2018, p. 6923-6926.

Research output: Contribution to journalArticle

Levalley, Paige J. ; Ovadia, Elisa M. ; Bresette, Christopher A. ; Sawicki, Lisa A. ; Maverakis, Emanual Michael ; Bai, Shi ; Kloxin, April M. / Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications. In: Chemical Communications. 2018 ; Vol. 54, No. 50. pp. 6923-6926.
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