Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications

Paige J. Levalley, Elisa M. Ovadia, Christopher A. Bresette, Lisa A. Sawicki, Emanual Michael Maverakis, Shi Bai, April M. Kloxin

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

An approach for the design of functionalized cyclic peptides is established for use in 3D cell culture and in cell targeting. Sequential orthogonal click reactions, specifically a photoinitiated thiol-ene and strain promoted azide-alkyne cycloaddition, were utilized for peptide cyclization and conjugation relevant for biomaterial and biomedical applications, respectively.

Original languageEnglish (US)
Pages (from-to)6923-6926
Number of pages4
JournalChemical Communications
Volume54
Issue number50
DOIs
StatePublished - Jan 1 2018

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ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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